2型糖尿病肾病患者红细胞膜上钠钾ATP酶活性的变化  

The Changes of Na^+-K^+-ATPase Activity in the Erythrocyte Member of Patients with Type Ⅱ Diabetes with Diabetic Nephropathy

作　　者：刘春[1] 杨晓萍[1] 马雅静[2] 周祖钊[3] 吴锡雄[2] 张金平[1] 程红新[1] 史新辉[1] 

机构地区：[1]石河子大学医学院一附院肾病科,新疆石河子832008 [2]石河子大学医学院一附院检验科,新疆石河子832008 [3]石河子大学医学院医学系,新疆石河子832002

出　　处：《石河子大学学报（自然科学版）》2005年第1期27-29,共3页Journal of Shihezi University(Natural Science)

摘　　要：为了解 2型糖尿病肾病 (diabeticnephropathy ,DN)不同时期红细胞膜上Na+ K+ ATP酶活性变化 ,为临床诊断、治疗提供理论依据 ,按尿白蛋白排泄率 (urinaryalbuminexcretionrate,UAER)将已确诊为 2型糖尿病的 5 1例患者分为 3组 :糖尿病正常白蛋白尿组 (DM1 组 ) ,微量白蛋白尿组 (DM2 组 ) ,大量白蛋白尿组 (DM3组 ) ;2 0例健康人作为对照组 ,男性 11例 ,女性 9例 ,平均年龄 5 8.2 7± 10 .89岁。将对照组及实验组抽血做红细胞膜Na+ K+ ATP酶活性检测。结果表明 :DN各组红细胞膜Na+ K+ ATP酶活性较对照组均显著降低 (均为P =0 .0 0 0 )。说明DN患者红细胞膜Na+ K+ ATP酶活性下降 ,控制血糖、维持Na+ K+To measure Na^+-K^+-ATPase activity in the erythrocyte member of patients with type 2 diabetes with diabetic nephropathy in different stage,so as to provide theoretical bases for some clinical diagnoses and treatment.51 patients were divided into 3 groups including normoalbuminuric group(DM_1 group),microalbuminuric group(DM_2 group) and macroalbuminuric(DM_3 group). Normal control group was made of 20 subjects including 11 men and 9 women,average age being 58.27±10.89 .The blood samples were withdrawn in control group and tested group to detect Na^+-K^+-ATPase activity in the erythrocyte member.The results showed that Na^+-K^+-ATPase activity in erythrocyte member was significantly lower in each group than that of the control group (P=0.001).It demostrated that Na^+-K^+-ATPase activity in erythrocyte member was decreased in diabetic nephropathy. The controlling of blood glucose and remaining of Na^+-K^+-ATPase activity had important significance to improve diabetic nephropathy.

关 键 词：糖尿病肾病 钠-钾ATP酶活性 尿白蛋白排泄率 

分 类 号：R587.1[医药卫生—内分泌]