111例肺结核合并下呼吸道感染的菌种分布及药敏分析  

The bacterial strains' distribution and antimicrobiol susceptibility analysis of 111cases of tuberculosis accompanied with lower respiratory infection

作　　者：秦超[1] 于维琴[1] 夏俊娣[1] 

机构地区：[1]天津市海河医院,天津300350

出　　处：《中国防痨杂志》2005年第2期93-96,共4页Chinese Journal of Antituberculosis

摘　　要：目的　统计分析肺结核合并下呼吸道感染的菌种分布及药物敏感情况。方法　统计天津市肺科医院 2 0 0 2年间肺结核合并下呼吸道感染 111例以及同期天津市 10家医院 12 39例下呼吸道感染痰标本中分离出菌株的菌种分布。对肺炎克雷伯杆菌、绿脓杆菌、鲍曼不动杆菌、液化沙雷氏菌的药敏进行统计分析 ,全部数据由SPSS软件进行分析处理。结果　肺结核合并下呼吸道感染细菌种类至少有 2 8种 ,依其所占比例高低排列前 8位依次是 :肺炎克雷伯杆菌 (19. 8% )、绿脓杆菌 (13. 5 % )、鲍曼不动菌 (9. 9% )、白色念珠菌 (7 .2 % )、液化沙雷氏菌 (5 . 4 % )、金黄色葡萄球菌 (5 . 4 % )、大肠杆菌(4. 5 % )、阴沟杆菌 (2 . 7% )。结论　阿米卡星、环丙沙星对感染率最高的四种病原菌都有很高的的敏感性 ,同时二者还被列为二线抗结核药物 ,故此可以作为肺结核 (特别是复治肺结核 )合并下呼吸道感染经验治疗的首选抗生素。Objective To determine the bacterial strains' distribution of tuberculosis accompanied with lower respiratory infection and select sensitive drugs. Method The isolated strains from 111 cases with tuberculosis accompanied with lower respiratory infection in our hospital during 2002 and 1239 contemporary cases in another 10 hospitals in Tianjin were reviewed. We focused on the distribution of their bacterial strains and the results of Antimicrobiol Susceptibility test on Klebsiella pneumoniae, Pseudomonas aeruginosa,Acinetobader baumannii,Serratia liquefaciens. All data were analyzed by SPSS software. Result There were 28 kinds of pathogenetic bacterial infection.The top 8 among these were Klebsiella pneumoniae(19 8%), Pseudomonas aeruginosa(13 5%), Acinetobader baumannii (9 9%),Monilia albicans (7 2%),Serratia liquefaciens (5 4%),Stap.aureus (5 4%),E.coli (4 5%) and E.cloacae (2 7%) respectively. Conclusions The four pathogenic bacterium with top high infection rates were all highly sensitive to Amikacin and Ciprofloxacin. Furthermore, Amikacin and Ciprofloxacin were both effective on tubercle bacillus and have been served as the second-line drug for antituberculosis. Therefore, they should be the first choice of the antibiotics for tuberculosis (especially for previously treated pulmonary tuberculosis ) accompanied with lower respiratory infection.

关 键 词：肺结核 并发症 下呼吸道感染 菌种分布 药敏分析 

分 类 号：R521[医药卫生—内科学]