3-巯基-5-芳香基-4-芳基亚甲胺基-4H-1,2,4-三唑的合成及波谱研究  

Synthesis and NMR Study of 4-(Arylmethylidene)-amino-5-aryl-3-mercapto-4H-1,2,4-triazoles

作　　者：张安将[1] 张力学[1] 丁金昌[1] 

机构地区：[1]温州师范学院药物研究所,温州325027

出　　处：《有机化学》2005年第4期442-444,共3页Chinese Journal of Organic Chemistry

基　　金：教育部高等学校骨干教师资助计划基金(No.1812)资助项目.

摘　　要：5-取代-4-氨基-3-巯基-1,2,4-三唑与芳香醛在弱酸性乙醇溶液中反应,合成了一系列3-巯基-5-芳香基-4-芳基亚甲胺基-4H-1,2,4-三唑(3a～3d)及水溶性的3-巯基-5-(D-葡萄糖-1-基)-4-(4-氯代苯基)亚甲胺基-4H-1,2,4-三唑(3e)新化合物.以元素分析,IR,NMR,MS实验技术对其结构进行了表征,并研究其NMR波谱特征.4-(Arylmethylidene)amino-5-aryl-3-mercapto-4H-1,2,4-triazoles (3a～3d) and 4-(4-chloroph- enylmethylidene)amino-5-(D-gluco-pentitol-1-yl)-3-mercapto-4H-1,2,4-triazole (3e) were synthesized in good yields by reaction of 4-amino-3-mercapto-5-substituent-1,2,4-triazole with aryl aldehyde in ethanolic medium. Their structures were confirmed by elemental analysis, IR, NMR, MS spectra and the characteris-tics of NMR spectra were also discussed.

关 键 词：甲胺基 巯基 三唑 芳基 香基 合成 D-葡萄糖 乙醇溶液 元素分析 新化合物 实验技术 波谱特征 NMR 弱酸性 芳香醛 水溶性 苯基 IR 

分 类 号：TQ450.1[化学工程—农药化工]