N-甲氧基-N-[2-(1,6-2H-1-取代-6-羰基-哒嗪-3-氧甲基)苯基]氨基甲酸甲酯的合成及生物活性研究  

Synthesis and Biological Activity of Methyl N-Methoxy-N-[2-(1,6-dihy- dro-1-substituent-6-oxo-pyridazin-3-yloxymethyl)phenl]carbamates

作　　者：刘卫东[1] 李志伟[2] 李仲英[2] 王晓光[1] 高必达[3] 

机构地区：[1]湖南化工研究院国家南方农药创制中心湖南基地,长沙410007 [2]湖南大学化学化工学院,长沙410082 [3]湖南农业大学生物安全科技学院,长沙410128

出　　处：《有机化学》2005年第4期445-448,共4页Chinese Journal of Organic Chemistry

基　　金：国家十五科技攻关(No.2004BA308A22);湖南省杰出青年科学基金(No.04JJ1009)资助项目.

摘　　要：为了寻找高效、低毒的农药,设计合成了一系列新的N-甲氧基-N-[2-(1,6-2H-1-取代-6-羰基-哒嗪-3-氧甲基)苯基]氨基甲酸甲酯化合物3a～3k,其结构经IR,1HNMR,LC/MS和元素分析确认.生物活性测定表明,部分化合物在50mg/L下对小麦赤霉病菌(Gibberellazeae)、稻瘟病菌(Pyriculariaoryzae)和黄瓜灰霉病菌(Botrytiscinerea)有较好的抑菌活性.In an attempt to find novel compounds with high activity and low toxicity, a series of novel methyl N-methoxy-N-[2-(1,6-dihydro-1-substituent-6-oxo-pyridazin-3-yloxymethyl)phenyl]carbamate derivatives 3a similar to 3k were designed and synthesized by bioisoster principle. Their structures were confirmed by (1)H NMR, IR, LUMS spectra and elemental analysis. The preliminary biological activity tests show that some compounds possess fungicidal activities against Pyricularia oryzae, Botrytis cinerea and Erysiphe graminis.

关 键 词：氨基甲酸甲酯 甲氧基 活性研究 苯基 甲基 哒嗪 羰基 生物活性测定 小麦赤霉病菌 黄瓜灰霉病菌 LC/MS 设计合成 元素分析 稻瘟病菌 抑菌活性 化合物 ^1H NMR IR 

分 类 号：TQ450.1[化学工程—农药化工]