依普黄酮对绝经后妇女骨质疏松性骨折愈合的临床研究  

Curative effect of ipriflavone on the union after fracture of postmenopausal womenwith osteoporosis

作　　者：涂平生[1] 黄自为[1] 曾颖[1] 徐杰[2] 

机构地区：[1]广州市番禺区中医院骨一区,511400 [2]中山大学医学院解剖教研室

出　　处：《中国药物与临床》2005年第3期190-191,共2页Chinese Remedies & Clinics

基　　金：广州市科技计划资助项(2003J1-C0161)

摘　　要：目的探讨依普黄酮对骨质疏松性骨折愈合影响。方法对60例绝经后骨质疏松性骨折的患者随机分成试验组(口服依普黄酮)、对照组,比较两组在治疗后3个月时的X线下的骨痂的变化,血清骨性碱性磷酸酶(BALP)、Ⅰ型前胶原羧基端肽(PICP)、骨钙素(BGP)骨形成生化指标及骨强度检测结果的变化情况。结果试验组BALP、PICP、OC水平显著下降(P<0郾01),而两组骨强度差异无统计学意义(P>0郾05)。结论依普黄酮对绝经后妇女可调节骨代谢,促进骨形成,对骨质疏松性骨折临床愈合有明显作用。O bjective To view the curative effect of estrogen replacem ent on wom en with postm enopausal fracture ofosteoporosis. M ethods Sixty cases ofpostm enopausalosteoporosis were divided into experim entalgroup (ipriflavone given orally) and controlgroup.The clinically effective rates and bone m etabolism indexes including bone m ineraldensity,bone gliacontaining protein (BG P),calcitonin and parahorm one were m easured. R esults The levels ofBG P,calcitonin and parahorm one decreased significantly (P<0.01),butthere was no clear difference ofBM D in two group (P>0.05). C onclusion Ipriflavine has obvious curative effecton osteoporotic fracture in the postm enopacusal wom en,itprom otes bone form ation and clinicalunion afterfracture.

关 键 词：绝经后妇女 依普黄酮 骨折愈合 临床研究 骨质疏松性骨折 Ⅰ型前胶原羧基端肽 骨性碱性磷酸酶 变化情况 检测结果 生化指标 BALP PICP 临床愈合 骨形成 对照组 治疗后 骨强度 骨钙素 统计学 强度差 骨代谢 可调节 试验 

分 类 号：R683[医药卫生—骨科学]