舌下含服米索前列醇对药物流产结局影响的临床研究  

Effect of Sublingual Misoprostol with Mifepristone in Medical Abortion

作　　者：王秀丽[1] 张石玲[1] 霍密英[1] 

机构地区：[1]河北省人民医院妇产科,石家庄050051

出　　处：《中国计划生育学杂志》2005年第4期240-242,共3页Chinese Journal of Family Planning

摘　　要：目的:探讨舌下含服米索前列醇对药物流产结局的影响。方法:将208例妊娠天数<49天的早孕妇女随机分组,对照组常规口服米非司酮配伍米索前列醇,观察组口服米非司酮配伍舌下含服米索前列醇,药物剂量相同。结果:观察组和对照组完全流产率分别为96.0%和89.1%,不全流产率为3.0%和5.9%,流产失败率为1.0%和5.0%(P<0.05);两组阴道持续出血时间分别为12.8±4.4天和13.1±4.5天,两组出血量无显著性差异;观察组中出现寒颤的例数比对照组明显增加(P<0.001),其它副反应比较无显著性差异(P>0.05)。结论:应用米非司酮片配伍舌下含服米索前列醇可提高完全流产率,值得临床推广。Objective: To assess the efficacy and side effects of sublingual misoprostol for terminating pregnancy of less than 7 weeks gestation. Method: A total of 208 women who requested legal termination of pregnancy up to 49 days were randomized into two groups and given 150mg oral mifepristone followed 48h later by either 600ug sublingual (104 cases) or oral (104 cases) misoprostol. Results: Complete abortion occurred in 96.0% of women in the sublingual group and 89. 1% in the oral group. There were five ongoing pregnancies in the oral group but one in the sublingual group. The average duration of vaginal bleeding was 12. 8 days in sublingual group and 13. 1 days in oral group. There was no significant difference between two groups. There was no serious complication in two groups. Chills was significantly more common in the sublingual group. Conclusions : The combination of sublingual misoprostol and mifepristone has higher complete abortion than oral misoprostol and mifepristone, and it is worthy of being widely used.

关 键 词：舌下含服 流产结局 临床研究 米非司酮配伍米索前列醇 完全流产率 显著性差异 米非司酮片 对照组 观察组 随机分组 早孕妇女 药物剂量 出血时间 失败率 出血量 副反应 口服 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]