复方蒿甲醚临床治疗恶性疟的效果观察  

CLINICAL EFFICACY OF CO-ARTEMETHER IN THE PATIENT WITH FALCIPARUM MALARIA

作　　者：单成启[1] 刘光裕[1] 焦岫卿[1] 

机构地区：[1]军事医学科学院微生物流行病研究所,北京100071

出　　处：《寄生虫与医学昆虫学报》2005年第1期14-16,共3页Acta Parasitologica et Medica Entomologica Sinica

摘　　要：为了观察复方蒿甲醚治疗恶性疟的临床疗效 ,以显微镜血检恶性疟原虫阳性患者为观察对象 ,复方蒿甲醚口服 ,3天 4次疗法 ,首剂服 4片 ,8、 2 4、 4 8h各服 4片 ,总剂量为 16片 ,服药后按时测量体温和血检原虫 ,并随访 2 8天 ,观察治疗效果。结果显示复方蒿甲醚治疗恶性疟 16 7例 ,平均退热时间为 2 0 . 4±8 4h ,原虫转阴时间为 37. 9± 7 9h ,2 4h原虫平均下降率 97. 4 % ,2 8天治愈率为 94 . 1% ,药后无明显不良反应。可见复方蒿甲醚治疗恶性疟疾具有良好的临床效果。To observe the clinical efficacy of compound artemether in patients with Falciparum malaria,Patients with Plasmodium falciprum were selected and treated with compound artemether by the administration of 4 times in 3 days, administered 4 pieces at first, and 8,24,and 48 hours later, totals 16 pieces. After drug administration, performed the blood film test and temperature examination in preselective time,followed up for 28 days to observe the fever clearance time and the parasite clearance time.Results obtained show among 167 patients with falciprum malaria treated with compound artemether ,the mean fever clearance time is 20.4±8.4 hours, the mean parasite clearance time is 37.9±7.9 hours. The mean parasite clear rate in 24 hours is 97.4% ,The cure rate of 28 days is 94.1% and no apparent side effect was observed. So compound artemether might be an effective drug for falciparum malaria infection.

关 键 词：蒿甲醚 恶性 复方 效果观察 临床治疗 临床疗效 治疗效果 不良反应 临床效果 疟原虫 显微镜 总剂量 治愈率 时间 平均 口服 体温 服药 

分 类 号：R531.3[医药卫生—内科学]