苯那普利对肾性高血压大鼠血管内皮功能的影响  

Effects of benazepril on the function of endothelium in rats with renal hypertension

作　　者：赵金晶[1] 邢俊杰[2] 吴桂平[2] 李亘松[1] 

机构地区：[1]中国医科大学基础医学院生理学教研室 [2]沈阳医学院附属第二医院心内科

出　　处：《中国医科大学学报》2005年第2期121-122,共2页Journal of China Medical University

摘　　要：目的: 探讨苯那普利对肾性高血压大鼠的降压疗效及对肾素血管紧张素系统(RAS)和血管内皮功能的影响。方法: 制备高血压大鼠模型,给予苯那普利,观察降压效果,治疗5周,分别应用放免法和硝酸还原酶法测定血浆血管紧张素Ⅱ(AngⅡ)和一氧化氮(NO)的浓度。结果: 治疗后血压明显下降(P<0.01);治疗后血浆AngⅡ水平降低,NO水平增高,治疗前后有显著差异(P<0.01)。结论: 苯那普利对肾性高血压治疗有效,并可改善血管内皮功能。Objective: To explore the effect of benazepril on serum angiotensin II(Ang II) and nitric oxide(NO)in rats with renal hypertension. Methods: The rats with renal hypertension were treated with benazepril for 5 weeks. The plasma levels of NO and AngⅡwere measured before and after the treatment.Results: The plasma level of AngⅡwith hypertension was significantly higher (P<0.01), but the plasma level of NO was lower than those of controls (P<0.01). After the treatment , the blood pressure decreased significantly (P<0.01). The plasma level of NO increased and that of AngII decreased (P<0.01). Conclusion: The treatment of benazepril plays an important role not only in reducing the blood pressure but also in protecting the endothelial function.

关 键 词：高血压 苯那普利 血管紧张素 一氧化氮 

分 类 号：R544.1[医药卫生—心血管疾病]