早期自然流产中卵泡休止素的变化及与HCG的相关研究  

Changes of follistatin in early spontaneous abortion and its correlation with human chorionic gonadotropin

作　　者：刘波[1] 尚涛[1] 

机构地区：[1]中国医科大学附属第二医院妇产科

出　　处：《中国医科大学学报》2005年第2期169-170,共2页Journal of China Medical University

摘　　要：目的:探讨早期自然流产中卵泡休止素(FS)的变化,比较其与人绒毛膜促性腺激素(HCG)有无相关性以及FS的高低与妊娠结局有无关系.方法:应用酶联免疫法对早期自然流产孕妇、正常早期妊娠孕妇血清FS进行测定,用放射免疫法对上述2组妊娠42～43 d的孕妇进行HCG测定.结果:早期自然流产孕妇组血清FS和HCG水平明显低于正常早期妊娠孕妇组(P＜0.01),保胎失败孕妇组血清FS水平明显低于保胎成功孕妇组(P＜0.01),FS与HCG的变化在早期自然流产及正常早期妊娠中均呈正相关.结论:血清FS水平的变化参与了早期妊娠的维持,FS减少容易引起早期自然流产,FS值的高低决定了早期自然流产的妊娠结局.Objective: To investigate the changes of the serum level of follistatin (FS) in early spontaneous abortion and its correlation with human chorionic gonadotropin (HCG), and to study the correlation between the serum level of FS and pregnant results. Methods: By using ELISA method, we measured the level of FS in 30 women with early spontaneous abortion and 30 women with normal pregnancy. With radio immunoassay, we examined the level of HCG in the women who have been pregnant for 42 to 43 days. Results: The serum concentrations of FS and HCG in women with early spontaneous abortion were significantly lower than those with normal pregnancy (P<0.01). The changes of FS were positively correlated with HCG in all these women. The serum concentration of FS in the group which was failure in keeping the pregnancy was significantly lower than that in the group which was successful. Conclusion: The changes of FS involves in the maintaining of early pregnancy. Decrease of FS may cause early spontaneous abortion. The result of pregnancy is affected by the serum concentration of FS.

关 键 词：卵泡休止素 人绒毛膜促性腺激素 早期自然流产 

分 类 号：R714.21[医药卫生—妇产科学]