早产低质量儿暂时性低甲状腺素血症及危险因素  

Study on the Incidence and Risk Factors of Transient Hypothyroxinemia in Premature and Low-birth-weight Infants

作　　者：刘群[1] 屠青[2] 于文红[1] 孙夫强[1] 张平平[1] 刘瑞霞[1] 

机构地区：[1]天津医科大学第二医院新生儿科,300211 [2]天津医科大学公共卫生学院营养与食品卫生教研室

出　　处：《天津医药》2005年第4期211-213,共3页Tianjin Medical Journal

摘　　要：目的:了解早产低体质量儿暂时性低甲状腺素血症(THP)的发生情况,分析其危险因素。方法:对早产低体质量儿生后筛查甲状腺素(T4),促甲状腺素(TSH),计算THP的发生率,分析其发生的危险因素。结果:胎龄≤32周组THP的发生率为64%,明显高于33～36周组及≥37周组;出生体质量≤1500g组THP的发生率为80%,明显高于1501～2499g组及≥2500g组,差异具有统计学意义。经多因素Logistic回归分析示出生体质量、呼吸窘迫综合征、红细胞增多症,母亲妊娠高血压综合征及产前感染与THP发生相关。结论:胎龄≤32周或出生体质量≤1500g的早产低体质量儿THP发生率分别为64%及80%。新生儿低出生体质量、呼吸窘迫综合征及红细胞增多症是THP的危险因素。Objective: To investigate the incidence of transient hypothyroxinemia (THP) in premature and low-birth-weight infants and analyze its risk factors. Methods: T4 and TSH were measured in premature and low-birth-weight infants.The incidence of THP was calculated and the risk factors were analyzed. Results: The incidence of THP in the group which gestational age was younger than 32 weeks (64%) was significantly higher than those which gestational age was equal to 33-36 weeks or longer than 37 weeks.The incidence of THP in the group which birth weight was less than 1 500 g (80%) were significantly higher than those in the groups which birth weight was equal to 1 501-2 499 g or greater than 2 500 g. There was a statistical significance of the differences. Neonatal birth weight, respiratory distress syndrome, polycythemia, pregnancy-induced hypertension and infection before delivery were correlative with THP by multivariate regression analysis. Conclusion: The incidence of THP were 64% and 80% respectively in infants which gestational age was younger than 32 weeks and birth weights less than 1 500 g. Neonatal low birth weights, respiratory distress syndrome and polycythemia are risk factors for THP.

关 键 词：暂时性低甲状腺素血症 危险因素 多因素Logistic回归分析 早产 呼吸窘迫综合征 妊娠高血压综合征 红细胞增多症 低体质量 低出生体质量 THP 促甲状腺素 发生率 发生情况 产前感染 统计学 新生儿 胎龄 

分 类 号：R722.12[医药卫生—儿科] R179[医药卫生—临床医学]