伊维菌素治疗肠道线虫感染临床试验观察  

CLINICAL EXPERIMENTAL OBSERVATION ON THE EFFICACY OF IVERMECTIN IN THE TREATMENT OF INTESTINAL NEMATODE INFECTIONS

作　　者：詹福初[1] 闻礼永[2] 邵坚强[1] 杨纪顺[2] 李土荣[1] 李思温[2] 寿申岚[1] 吴玲娟[2] 

机构地区：[1]浙江省常山县疾病预防控制中心,浙江常山324200 [2]浙江省医学科学院寄生虫病研究所,浙江杭州310013

出　　处：《中国寄生虫病防治杂志》2005年第1期60-63,共4页Chinese Journal of Parasitic Disease Control

摘　　要：　目的　观察不同剂量、疗程的国产伊维菌素治疗肠道线虫感染的疗效及不良反应。　方法　以饱和盐水浮聚法筛选肠道线虫感染者,并观察伊维菌素疗效及不良反应。第 1 阶段对蛔虫、钩虫、鞭虫感染者分别以伊维菌素 0.1、0.15和0.2 mg/kg,蛲虫感染者 0.2 mg/kg顿服治疗,并与阿苯达唑 6.7 mg/kg(蛲虫感染者 13 mg/kg)顿服作疗效比较。第2阶段以伊维菌素0.3、0.4 mg/kg口服1 d或2 d治疗钩虫、鞭虫感染,并与阿苯达唑 6.7 mg/kg相同疗程作疗效比较。　结果　第1阶段:伊维菌素0.1、0.15、0.2 mg/kg顿服治疗蛔虫感染的治愈率均达 100%(44/44、8/8、8/8),与阿苯达唑疗效相同(100%)(34/34);治疗中度、重度钩虫感染者的治愈率分别为 12. 50% (2/16)、18. 75% (3/16)、17.39%(8/46),显著低于阿苯达唑治愈率76.47%(26/34)(P<0.01);治疗鞭虫感染者治愈率分别为 83.33%(10/12)、100%(12/12)和76.09%(35/46),显著高于阿苯达唑治愈率 47.06%(16/34)(P<0.01);0.2 mg/kg伊维菌素治疗蛲虫感染者治愈率为58.82%(20/34),低于阿苯达唑 13 mg/kg治愈率 100%(34/34)(P<0.01)。第 2 阶段:伊维菌素 0.3mg/kg口服1 d或2 d疗法对轻度钩虫感染者治愈率分别为85.29%(29/34)和79.41%(27/34),0.4 mg/kg口服1 d或2 d的治愈率分别为75.Objective To observe the clinical efficacy and side effects of ivermectin in the treatment of intestinal nematode infection with different dosage and period of treatment. Methods The method of staturated brine floatation was used to exam infection cases of intestinal nematode and evaluate the efficacy and the side effect of ivermectin. In the first stage, a single dose of ivermectin 0.1, 0.15 and 0.2 mg/kg were orally administered to persons who infected with ascaris, hookworm and trichuris respectively, and 0.2 mg/kg with enterobius. A single dose of albendazole 6.7 mg/kg (enterobius 13 mg/kg) was orally administered as control. In the second stage, ivermectin 0.3 and 0.4 mg/kg for 1 d or 2 d were orally administered to persons infected with hookworm and trichuris respectively. Albendazole 6.7 mg/kg was orally administered as control. Results In the first stage, the cure rates of ivermectin 0.1 , 0.15, 0.2 mg/kg and albendazole 6.7 mg/kg were 100.00%(44/44, 8/8, 8/8, 34/34) for ascaris infection; were 12.5%(2/16), 18.75%(3/16), 17.39%(8/46) and 76.47%(26/34) respectively for moderate and heavy hookworm infection. The efficacy of the group treated by ivermectin was significantly lower than that of albendazole( P <0.01). The cure rates of ivermectin 0.1, 0.15 and 0.2 mg/kg for trichuris infection were 83.33%(10/12), 100.00%(12/12), 76.09%(35/46) respectively, and were significantly higher than that of albendazole(6.7 mg/kg), which was 47.06%(16/34) ( P <0.01). The cure rates of ivermectin 0.2 mg/kg and albendazole 13 mg/kg were 58.82%(20/34) and 100.00%(34/34) respectively for enterobius infection( P <0.01). In the second stage, the cure rates of ivermectin 0.3 mg/kg×1 d, 0.3 mg/kg×2 d, 0.4 mg/kg×1 d, 0.4 mg/kg×2 d and albendazole 6.7 mg/kg×1 d were 85.29%(29/34), 79.41%(27/34), 75.76%(25/33), 79.41%(27/34) and 84.85%(28/33) respectively for slight hookworm infection ( P >0.05). The side effect rate was 0.68 %(3/442) of ivermectin which was less than 11.02%(26/236) of albendazole( P <0.01

关 键 词：伊维菌素 蛔虫 钩虫 鞭虫 蛲虫 临床试验 

分 类 号：R383.1[医药卫生—医学寄生虫学]