子宫肌瘤组织在注入甲氨蝶呤后的病理学改变  

Pathological changes in hysteromyoma after injection of methotraxate

作　　者：苑洪菲[1] 伏胜香[1] 崔红艳[1] 孙淑清[1] 薛红艳[1] 车丽萍[1] 

机构地区：[1]武警黑龙江总队医院妇产科,哈尔滨150076

出　　处：《武警医学》2005年第3期187-189,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的　探讨子宫肌瘤在注入MTX(甲氨蝶呤 )后缩小的机制。方法　对 5例子宫肌瘤在注入MTX半个月及 1个月后行手术治疗 ,对其标本进行了光镜和电镜观察并与同期未注药标本进行了比较。结果　所有注入MTX的标本光镜下 ,均可见明显的平滑肌细胞的水肿、变性 ,单位视野内的血管数目明显减少 ,血管腔变窄 ;电镜下见平滑肌细胞内变性、水肿、扩张的内质网和线粒体等。结论　MTX的缩瘤效果是通过减少肌瘤内的血供和直接的细胞凋亡来完成的。Objection To study the mechanism of shrinkage of hystero myoma after injectiong methotraxate (MTX).Methods Five patients with hysteromyoma under went operative treatment half a month and one month after injection of MTX .The tumr specimens were examined under light microscope and electron microscope, and compared with those specimens without injection of MTX.Results Light microscopically,all the MTX injected specimens showed edema and degeneration in smooth muscle cells.Electron microscopically,degerated,edematous and dilated endoplasmic reticula and mitochondria in smooth muscle cells were visualized.Conclusion The effect of MTX on shrink age of hystero Myoma is achieved by direct cell apoptosis and blood supply reduction.

关 键 词：甲氨蝶呤 病理学改变 注入 肌瘤组织 平滑肌细胞内 子宫肌瘤 MTX 手术治疗 电镜观察 细胞凋亡 标本 血管数 血管腔 线粒体 内质网 镜下 水肿 变性 

分 类 号：R714.22[医药卫生—妇产科学] R512.6[医药卫生—临床医学]