中国拟青霉对小鼠免疫性肝损伤的保护作用  

Protective effects of CN802 on immunological liver injury in mice

作　　者：成亮[1] 徐平湘[1] 唐玉[1] 

机构地区：[1]首都医科大学药理学教研室,北京100054

出　　处：《中国临床药理学与治疗学》2005年第3期318-320,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:研究中国拟青霉(CN 80 2 )对小鼠免疫性肝损伤的保护作用及其对T淋巴细胞亚群的影响。方法:小鼠尾静脉注射卡介苗加脂多糖(BCG +LPS)建立免疫性肝损伤模型,检测其肝、脾重量和转氨酶活性,并同时测定血清与肝组织中脂质过氧化物(LPO)含量及T淋巴细胞亚群数量。结果:CN 80 2连用10d后可减轻其增大的肝、脾重量指数,降低小鼠血清中谷丙转氨酶(ALT)水平,降低其血清与肝组织中LPO含量,并增加外周血中T细胞亚群CD4数量和CD4 CD8比值。结论:CN 80 2对小鼠免疫性肝损伤模型有保护作用,其作用可能与调节细胞免疫有关。AIM: To study the protect effects of paecilomyceps sinensis sp nov (CN-802) on immunological liver injury in mice which induced by BCG+LPS. METHODS: LPS was injected into mice via the tail vein pretreated with BCG. The activity of serum ALT, the weighing indexes of liver and spleen, the levels of LPO in serum and hepatic tissues, and the numbers of subgroup of T lymphocyte were determined respectively. RESULTS: CN-802 at dose of 1.0 g·kg -1·d -1 decreased the serum ALT level, the liver and spleen-enlarged index and the LPO levels in serum and hepatic tissues. Analysis of CD_4/CD_8 in the peripheral blood showed that CN-802 increased the number of CD_4 lymphocyte and the ratio of CD_4/CD_8. CONCLUTION: Pretreatment with CN-802 prevents the immunological liver injury induced by BCG+LPG, and the effect of CN802 may be related with the regulatory of immune cells.

关 键 词：中国拟青霉 免疫性肝损伤 卡介苗 脂多糖 T淋巴细胞亚群 

分 类 号：R966[医药卫生—药理学]