血管内皮细胞非神经性乙酰胆碱系统的研究进展  

Research progress of non-neuronal acetylcholine systems in endothelium

作　　者：陈凯[1] 汪海军 

机构地区：[1]事医学科学院毒物药物研究所,北京100850

出　　处：《中国临床药理学与治疗学》2005年第3期254-258,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家"973"重点基础研究发展规划项目 (№G19980 5 1112 ) ;北京赛德维康医药研究院新药研究基金资助项目 (№ 19990 0 1)

摘　　要：血管内皮细胞作为人体主要的代谢库,存在ACh ,并伴有ChAT的表达,有机阳离子载体(OCTs)参与血管内皮细胞ACh的转运和释放,血管内皮细胞AChE活性的广泛表达可以使非神经性ACh的活性仅仅局限于它的合成和释放区域,成为一种细胞因子。mAChR和nAChR同非神经性ACh一样,广泛存在于血管内皮细胞中,ACh通过其受体发挥重要的病理生理功能。nAChR参与血管内皮细胞多种生物活性物质的分泌和释放,其中α7受体在血管新生中发挥重要作用。非神经性ACh诱发内皮依赖的血管舒张反应,一种不同于神经性mAChR的血管内皮细胞非神经性M受体在其中发挥重要作用,并且在动脉粥样硬化和血栓的发生发展过程中起着重要的作用。ACh widely distributes in non nervous tissues and cells. The organic cation transporters (OCTs) are involved in the transportation and release of ACh. Wide expressions of AChE in endothelium limit the effects of non neuronal acetylcholine on the area of its synthesis and release and it makes the non neuronal acetylcholine be a cytokine. Muscarinic and nicotinic receptors are widely expressed on endothelial cells in comparison with the distribution of non neuronal acetylcholine. Nicotinic receptors are involved in the synthesis and release of several bioactivity molecules. The α 7 subtype of nicotinic receptors participates in the angiogenesis. Non neuronal acetylcholine induces the vascular relaxation with intact endothelium. The endothelial target for acetylcholine different from neuronal acetylcholine receptors plays an important role in vascular relaxation, and participates in the progress of atherosclerosis and thrombosis.

关 键 词：非神经性乙酰胆碱 内皮细胞 血管新生 动脉粥样硬化 血栓 

分 类 号：R966[医药卫生—药理学]