8-氯腺苷长循环脂质体的制备及其在大鼠体内的药代动力学  

Preparation of 8-chloro-adenosine long circulation liposomes and its pharmacokinetics in rats

作　　者：杨莉[1] 齐宪荣[1] 石靖[1] 陈文倩[1] 张强[1] 

机构地区：[1]北京大学药学院药剂系,北京100083

出　　处：《药学学报》2005年第4期382-384,共3页Acta Pharmaceutica Sinica

基　　金："十五"国家重大科技专项资助项目(2002AA2Z3143)

摘　　要：Aim To prepare 8-chloro-adenosine (8-Cl-A)long circulation liposomes with high entrapped efficiency and prolonged action-time of 8-Cl-A in vivo. Methods To prepare 8-Cl-A long circulation liposomes of nanometer size by improved multiple emulsion. The entrapped efficiency, size and size distribution of 8-Cl-A long circulation liposomes were determined, and its pharmacokinetics in rats was evaluated. Results The entrapped efficiency of 8-Cl-A long circulation liposomes was 62.70% and mean diameter of the liposomes was 79.9 nm. The pharmacokinetics studies indicated that 8-Cl-A long circulation liposomes showed higher drug concentration and larger AUC values than that of 8-Cl-A after iv to rats. Conclusion 8-Cl-A long circulation liposomes could prolong the action-time of 8-Cl-A in vivo.Aim To prepare 8-chloro-adenosine (8-Cl-A)long circulation liposomes with high entrapped efficiency and prolonged action-time of 8-Cl-A in vivo. Methods To prepare 8-Cl-A long circulation liposomes of nanometer size by improved multiple emulsion. The entrapped efficiency, size and size distribution of 8-Cl-A long circulation liposomes were determined, and its pharmacokinetics in rats was evaluated. Results The entrapped efficiency of 8-Cl-A long circulation liposomes was 62.70% and mean diameter of the liposomes was 79.9 nm. The pharmacokinetics studies indicated that 8-Cl-A long circulation liposomes showed higher drug concentration and larger AUC values than that of 8-Cl-A after iv to rats. Conclusion 8-Cl-A long circulation liposomes could prolong the action-time of 8-Cl-A in vivo.

关 键 词：8-氯腺苷 长循环脂质体 药代动力学 

分 类 号：R943.5[医药卫生—药剂学] R969.1[医药卫生—药学]