药瘾者庚型肝炎病毒感染状况及其影响因素  

The Prevalence and the Associated Risk Factors of HGV in Users

作　　者：黄元成[1] 田德英[1] 黄加权[1] 张振纲[1] 夏宁邵[2] 杨道锋[1] 陈红云[1] 雷洪波[1] 宋佩辉[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院感染科,湖北武汉430030 [2]厦门大学国家基因工程重点实验室

出　　处：《中西医结合肝病杂志》2005年第2期103-104,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：863课题资料 (1 0 2 - 0 7- 0 2 - 0 7)

摘　　要：目的:调查湖北地区药瘾者HGV感染状况及其影响因素。方法:检查药瘾者的血清HGV感染指标,用ELISA法检测抗 HGV。结果:716例药瘾者HGV的感染率为12 . 85 % (92例)。静脉药瘾者抗 HGV阳性率为16 96% ,口服药瘾者为5 . 73 % ,两者比较差异有显著性意义(χ2 =10 8 .3 1,P <0 .0 5 ) ,吸毒2年以上者抗 HGV阳性率显著高于吸毒2年以下者(χ2 =19. 2 9,P <0. 0 1) ;女性药瘾者的抗 HGV阳性率略高于男性药瘾者,但统计学分析差异无显著性意义(χ2 =1 .3 6,P >0 .0 5 ) ;3 45例女性药瘾者中卖淫者抗 HGV阳性率显著高于无卖淫史药瘾者(χ2 =4 10 ,P <0 . 0 5 ) ;HBsAg阳性者和HBsAg阴性者抗 HGV阳性率的差异无显著性意义(χ2 =1 3 .1,P >0 . 0 5 ) ;抗 HCV (+ )者和抗 HCV (-)者的抗 HGV阳性率差异有显著性意义(χ2 =19 .2 6,P <0. 0 1)。所有HGV感染者的肝功能正常。结论:药瘾者具有较高的HGV感染率。药瘾者HGV感染率与吸毒时间呈正相关。Objective:To survey the prevalence and the associated risk factors of HGV in the drug users.Methods:Anti-HGV was detected by ELISA.Results: The positive rate of HGV markers in drug rsers was 12.85% (92/716). The positive rate of Anti-HGV in iv drug users(16.96%)was higher than that in oral users (5.73%,χ 2=108.31, P <0.05). There weren t difference of positive rates of anti-HGV between female (14.49%)and male users (11.32%,χ 2=1.36, P >0.05);between users with positive HBsAg (14.22%)and users with negative HBsAg(11.04%,χ 2=1.31, P >0.05 ). However,difference were found between users addicted for more than 2 years (19.41%) and users for less than 2 years (8.01%,χ 2=19.29, P <0.01);between female with prostitution (22.37%)and female without prostitution(12.27,χ 2=4.01, P <0.05);between users with positive anti-HCV(16.99%)and users with negative anti-HCV(5.18%,χ 2=19.26, P <0.01).No abnormality of liver function was found in all of the cases with positive HGV markers.Conclusion: Drug addiction increases the risk of HGV infection.

关 键 词：庚型肝炎病毒感染状况 抗-HGV ELISA法检测 HBSAG阳性者 HBsAg阴性 阳性率 静脉药瘾者 统计学分析 肝功能正常 显著性 感染率 湖北地区 感染指标 吸毒时间 卖淫者 感染者 正相关 女性 

分 类 号：R512.6[医药卫生—内科学]