烧伤病房铜绿假单胞菌体外药物敏感性分析  

Analysis of susceptibility of Pseudomonas aeruginosa isolated from a burn ward to antibiotics in vitro

作　　者：张艳红[1] 邓诗琳[2] 刘金伟[1] 

机构地区：[1]天津市第四医院检验科,300222 [2]天津市第四医院烧伤科,300222

出　　处：《中华烧伤杂志》2005年第2期104-106,共3页Chinese Journal of Burns

摘　　要：目的　了解并分析笔者单位烧伤病房铜绿假单胞菌的分离情况及对抗生素的敏感性。方法　选择1997年1月—2003年9月笔者单位烧伤病房的536例住院患者,取其创面分泌物、静脉导管尖端、痂下组织及血液标本,用VITEK AMS系统进行细菌鉴定和药物敏感试验。　结果　1997—2003年各年间,铜绿假单胞菌的分离率分别为24. 51%、23. 94%、21. 01%、40. 06%、36. 17%、46. 76%、55 72%。第三代头孢菌素抗菌活性呈下降趋势, 1997年对头孢哌酮、头孢氨噻肟、头孢他啶的敏感率分别为71%、66%、79%; 1998年分别为47%、25%、39%; 2002年为22%、16%、25%;到2003年,第三代头孢菌素基本失去对铜绿假单胞菌的抗菌活性,头孢他啶的敏感率仅为2%。1997—2003年各年间,铜绿假单胞菌对亚胺培南的敏感率分别为76%、33%、45%、41%、11%、31%、4%,其中2003年最低。　结论　1997—1999年,笔者单位烧伤病房铜绿假单胞菌的分离率居于相对稳定的水平, 2000年起呈明显上升的趋势。该菌对抗生素的耐药性日趋严重,呈多重耐药性。Objective To analyze the isolation and the in vitro susceptibility of P. aeruginosa to antibiotics in our burn ward. Methods Five hundred and thirty six burn patients admitted to our ward from 1997 to 2003 were enrolled in the study, and the wound excretion, the tips of the venous catheter, the subeschar tissue samples, and the blood samples were collected for bacterial identification and antibiotic susceptibility test with VITEK-AMS system. Results The isolation rate of P. aeruginosa from 1997 to 2003 was 24.51%, 23.94%, 21.01%, 40.06%, 36.17%, 46.76% and 55.72%, respectively. The antibiotic effect of the third generation of Cephalosporins against the said bacteria showed a tendency to decline. The susceptibility rate to Cefoperazone, Ceftazidime and Cefotxime were respectively 71%, 66% and 79% in 1997; 47%,25%,39% in 1998; 22%,16%,25% in 2002; The third generation cephalosporins had almost lost their antibiotic activity against P. aeruginosa in 2003, with the susceptibility rate to Cefotxime lowered to 2%. The susceptibility rate to Imipenem from 1997 to 2003 was 76%,33%,45%,11%,41%,31%and 4%, repectively. Conclusion The isolation rates of P. aeruginosa were steady during the period from 1997 to1999, and they began to increase in 2000. The bacterial resistance to antibiotics increased gradually in recent years, and the strains of P. aeruginosa had become multi-drug resistant.[

关 键 词：铜绿假单胞菌 烧伤病房 药物敏感性分析 1997-1999年 第三代头孢菌素 2003年 1997年 体外 药物敏感试验 抗菌活性 头孢他啶 创面分泌物 VITEK 头孢氨噻肟 1998年 2002年 2000年 多重耐药性 敏感率 住院患者 静脉导管 血液标本 

分 类 号：R446.5[医药卫生—诊断学]