沙棘黄酮对链脲佐菌素致糖尿病大鼠降糖作用  

THE ANTIHYPERGLYCEMIC EFFECT OF FLAVONOIDS FROM HIPPOPHAE RHAMNOIDES L.ON DIABETIC RATS INDUCED BY STREPTOZOTOCIN

作　　者：曹群华[1] 瞿伟菁[1] 牛伟[1] 邓云霞[1] 王意文[1] 谢晶晶[1] 

机构地区：[1]华东师范大学生命科学学院,上海200062

出　　处：《营养学报》2005年第2期151-154,共4页Acta Nutrimenta Sinica

基　　金：上海市科技发展基金(No.014358009)

摘　　要：目的:研究沙棘籽渣和果渣中黄酮对链脲佐菌素(STZ)诱导糖尿病大鼠的降糖作用。方法:用STZ成功地制造了1型糖尿病大鼠模型,分别用沙棘籽渣中黄酮(FSH)和沙棘果渣中黄酮(FFH)连续灌胃4w。结果:与模型对照组相比,FSH极显著地降低STZ糖尿病大鼠血糖、果糖胺、血脂水平,提高血清白蛋白、总蛋白含量,增强机体抗氧化能力,对乳酸和肝糖原影响不大,同时可调节糖尿病大鼠的饮食水平;而FFH的作用效果不及FSH。结论:FSH能有效的控制糖尿病大鼠血糖水平,纠正其物质代谢紊乱。Objective: To study the antihyperglycemic effect of flavonoids from seed (FSH) and fruit(FFH) of Hippophae rhamnoides L.on diabetic rats induced by streptozotocin (STZ). Methods: The STZ-induced diabetic rats were randomly divided into four groups and were given intragastrically (ig) water, metformin, FSH and FFH respectively once a day. After four weeks, the levels of serum glucose, fructosamine, lipid, protein, GSH and lactic acid (LD) were assayed. Results: FSH could reduce the levels of serum glucose, fructosamine and triglyceride significantly, increase the contents of serum total protein and albumin obviously, enhance the ability of antioxidation in STZ-induced diabetic rats. FSH also could decrease food and water intake of diabetic rats evidently. But FSH had little effect on LD, LDH, glycogen and body weight in diabetic rats. FFH was not as good as FSH. Conclusion: FSH is antihyperglycemic , and can improve the metabolic derangements of STZ- induced diabetic rats.

关 键 词：沙棘黄酮 糖尿病 果糖胺 血清蛋白 

分 类 号：R285.5[医药卫生—中药学]