电针对更年期雌性大鼠雌激素水平及垂体ERα mRNA表达的影响  

Effect of electroacupuncture on E_2 of plasma and ERα mRNA expression of the pituitary in climacteric female rats

作　　者：祖英秋[1] 杨志国 田淑君[1] 

机构地区：[1]哈尔滨医科大学生理学教研室,黑龙江哈尔滨150086 [2]解放军空军466医院泌尿外科,北京100089

出　　处：《哈尔滨医科大学学报》2005年第2期127-129,共3页Journal of Harbin Medical University

摘　　要：目的　研究电针刺激对更年期雌性大鼠垂体功能的影响及机制。方法　应用放射免疫分析(Radioim munoassay ,RIA)测实验各组大鼠血中雌二醇(estradiol,E2 ) ,卵泡刺激素(folliclestimulatinghormone,FSH)和黄体生成素(luteinizinghormone ,LH)以及逆转录聚合酶链反应(reversetranscriptasepolymerasechainreaction ,RT PCR)测实验各组大鼠ERαmRNA表达产物。结果　电针处理后,大鼠血中E2 增加,FSH和LH降低,垂体ERαmRNA表达增加。结论　电针改善更年期雌性大鼠垂体功能可能是通过调节垂体雌激素受体实现的。Objective To study effects of eletroacupuncture on the function of the pituitary in climacteric female rats.Methods Spurred “ZUSANLI” in climacteric rats by electroacupuncture.Radio-immunoassay analysis and RT-PCR were used.Results In climacteric rats treated with electroacupuncture,estradiol(E_2) increased;FSH and LH decreased,and expression of ERα mRNA in pituitary increased.Conclusion The effects of eletroacupuncture improves the function of pituitary of climacteric rats,which may be related to eletroacupuncture's regulation of the expression of ERα mRNA in pituitary.

关 键 词：电针 垂体 更年期 雌激素受体 雌激素 

分 类 号：R335[医药卫生—人体生理学]