超临界抗溶剂技术制备对乙酰氨基酚-PEG4000固体分散体  

Application of supercritical antisolvent technology in the preparation of paracetamol-PEG4000 solid dispersions

作　　者：李冬兵[1] 王家炜[1] 杨基础[1] 

机构地区：[1]清华大学化工系,北京100084

出　　处：《中国抗生素杂志》2005年第4期198-203,共6页Chinese Journal of Antibiotics

摘　　要：以水难溶药物对乙酰氨基酚为模型体系,研究了超临界二氧化碳抗溶剂法(PCA和GAS)制备乙酰氨基酚-PEG分散体微细颗粒的影响因素,用电子扫描显微镜、X射线衍射仪和示差扫描量热仪研究了颗粒的物理性质,发现经PCA和GAS处理后,颗粒分散性增强,与水的接触面积增大,溶出速度和溶出量均随之增大。研究表明,超临界抗溶剂过程是制备固体分散体的一个可行的方法。Supercritical antisolvent processes for the preparations of pharmaceutical solid dispersions of paracetamol and PEG4000 have been studied. The correlations of the operation parameters on the processes were discussed. The physical characterization of the binary dispersions was determined using scanning electron microscopy, X-ray diffraction and differential scanning calorimetry. It was found that the dispersion and surface area of paracetamol in carrier PEG4000 were increased after PCA (precipitation with a compressed fluid antisolvent) and GAS (gas antisolvent sprany) process, and the dissolution were increased either. The studies proved that supercritical fluid antisolvent technology was an alternative method of preparing solid dispersion.

关 键 词：固体分散体 对乙酰氨基酚 聚乙二醇 超临界抗溶剂 微细颗粒 

分 类 号：TQ028[化学工程]