可溶性锰(IV)化学发光反应的研究  

Chemiluminescence Reaction with Soluble Manganese(IV) as the Oxidant

作　　者：何云华[1] 吕九如[1] 祝兴华[1] 杜建修[1] 

机构地区：[1]陕西师范大学化学与材料科学学院,西安710062

出　　处：《化学学报》2005年第8期729-733,共5页Acta Chimica Sinica

基　　金：国家自然科学基金(No.20275023);陕西省自然科学基础研究(No.2002B12)资助项目.

摘　　要：发现了在甲醛存在的条件下, 可溶性锰(IV)与30 余种有机物和无机物的化学发光反应. 以头孢菌素类药物(头孢曲松钠、头孢唑啉钠、头孢拉定和头孢哌酮钠)为分析对象优化了可溶性锰(IV)-甲醛-头孢菌素类药物化学发光反应的条件, 建立了测定四种头孢菌素类药物的流动注射化学发光新方法, 并将建立的方法用于药物制剂中头孢菌素类药物的含量测定.同时, 对化学发光反应的机理进行了初步探讨.It was found that soluble manganese(IV) could react with more than 30 organic and inorganic compounds to produce strong chemiluminescence signal in the presence of formaldehyde. The reaction con- ditions were optimized and a new flow injection chemiluminescence method for the determination of four cephalosporin drugs, namely ceftriaxone sodium, cefazolin sodium, cefradine and cefoperazone sodium, was established. The method was applied to the determination of cephalosporins in pharmaceutical preparations. Meanwhile, the chemiluminescence reaction mechanism was also discussed briefly.

关 键 词：可溶性锰 化学发光反应 甲醛 分析方法 头孢菌素药物 抗生素 药物分析 

分 类 号：O614.711[理学—无机化学]