单纯性肥胖儿童血浆血管紧张素II醛固酮对心脏结构的影响  

Effects of renin-angiotensin system on myocardial hypertrophy in simple adipose children

作　　者：李亚蕊[1] 王俊英[1] 杨蕊华[1] 崔涛[1] 王丽红[1] 嘉红云[2] 

机构地区：[1]山西医科大学儿科系,030001 [2]广东药学院儿科教研室

出　　处：《中国药物与临床》2005年第2期93-94,共2页Chinese Remedies & Clinics

基　　金：山西省科委攻关项目(022077)

摘　　要：目的探讨单纯性肥胖儿童血浆血管紧张素II、醛固酮变化对心脏结构的影响,为预防单纯性肥胖儿童发生心血管病疾患的方法提供理论依据。方法分别测量30例单纯性肥胖儿童和30例对照组儿童的体重指数(BMI),并采用彩色超声仪测量左室质量(LVM),同时测定血浆血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)浓度。结果①肥胖组AngⅡ,ALD均显著高于对照组(P<0.05),两组差异有统计学意义,说明血管紧张素醛固酮系统在儿童肥胖中的作用。②肥胖组LVM显著高于对照组,室间隔厚度(IVST),左室舒张末期内径(LVIDd),左室后壁厚度(LVPWT),LVM肥胖组分别为6.3±0.8,49.1±3.1,6.8±1.1,107.8±27.0;对照组为5.7±0.4,43.4±2.1,6.2±0.4,76.1±12.0,P值均<0.01。③肥胖组中AngⅡ,ALD均与LVM之间存在直线正相关和回归关系。回归系数t检验P均<0.05,AngⅡ,ALD浓度升高在引起LVM增加中起作用。结论肥胖组儿童存在的肾素-血管紧张素-醛固酮系统(RAAS)异常激活在引起其心肌肥厚中起作用。ALD与AngⅡ相互作用,增强了RAAS的活性,促进心肌肥厚的进一步发展。Objective To discuss the effects of angiotensin Ⅱ(Ang Ⅱ) and aldosterone(ALD) on myocardial hypertrophy in simple adipose childern. Methods Randomly selecting 31 simple adipose children and 31 normal children,to measure their body mass index(BMI),left ventricular mass(LVM) and serum levels of AngⅡ and ALD. Results Compared with the controls,adipose children had their serum levels of Ang Ⅱ and ALD significantly increased.LVM also increased significantly in adipose children.There was a positive linear correlation between Ang Ⅱ,ALD and LVM. Conclusion The abnormal activation of renin-angiotensin-aldosterone system (RAAS) exerts an effect on myocardial hypertrophy in simple adipose children.

关 键 词：单纯性肥胖 儿童 血浆血管紧张素Ⅱ醛固酮 心脏结构 

分 类 号：R723.14[医药卫生—儿科]