从细胞到器官——牙组织工程任重而道远  

Tooth tissue engineering: from cells to organ, an odyssey far from finished

作　　者：胡冰[1] 刘怡[1] 王松灵[1] 

机构地区：[1]首都医科大学口腔医学院基因治疗分子生物学实验室,北京100050

出　　处：《上海口腔医学》2005年第2期99-102,共4页Shanghai Journal of Stomatology

摘　　要：Tooth tissue engineering is an emerging biotechnique that will provide replacemental teeth for patients suffering from different diseases causing tooth loss. Although some attempts have been tried to generate whole tooth both in vivo and in vitro, the lack of the knowledge for tooth initiation and development, as well as for tooth shape controlling mechanisms greatly impede the progress of this technique. This article reviewed and discussed some recent findings in tooth tissue engineering related to the cell resource, the concept of reconstruction and regeneration, the application of artificial scaffolds, together with the methods of organ culture and implantation.Tooth tissue engineering is an emerging biotechnique that will provide replacemental teeth for patients suffering from different diseases causing tooth loss. Although some attempts have been tried to generate whole tooth both in vivo and in vitro, the lack of the knowledge for tooth initiation and development, as well as for tooth shape controlling mechanisms greatly impede the progress of this technique. This article reviewed and discussed some recent findings in tooth tissue engineering related to the cell resource, the concept of reconstruction and regeneration, the application of artificial scaffolds, together with the methods of organ culture and implantation.

关 键 词：细胞 器官 牙组织工程 牙发生发育 生物支架 

分 类 号：R318.0[医药卫生—生物医学工程]