医务人员SARS抗体研究初探  

Preliminary study on SARS antibodies in health care workers

作　　者：王琦[1] 尹炽标[1] 唐小平[1] 谭奕洲[1] 张顺玲[1] 

机构地区：[1]广州市第八人民医院,广东广州510060

出　　处：《中国感染控制杂志》2005年第2期154-156,共3页Chinese Journal of Infection Control

摘　　要：目的　探讨SARS感染者抗体产生的规律。方法　采用酶联免疫吸附法(ELISA)对某院2 0名患SARS的医务人员及4 4 5名未患SARS的医务人员的5 0 5份血清标本进行SARS抗体检测,并设75名社区健康成人为对照。结果　2 0名临床确诊感染SARS的医务人员,IgM抗体阳性率35 % (7/ 2 0 ) ,起病后3～4周阳性4 / 5例,5～8周阳性3/ 9例,9周后全部转阴性;IgG抗体阳性率95 % (19/ 2 0 ) ,起病后3～5周阳性5 / 5例,6～9周阳性10 / 10例,18周阳性19/ 2 0例,且抗体滴度较高。未患SARS的医务人员,IgM抗体阳性率为0 ,IgG抗体阳性率为2 .2 5 % (10 / 4 45 ) ;75例对照者IgM抗体阳性率为0 ,IgG抗体阳性率1.33%。结论　患SARS的医务人员IgG抗体阳性率较高;未患SARS的医务人员SARS抗体阳性率与社区人员相比无差异(P =0 .6 11) ;SARS在健康人群中存在隐性感染的可能。Objective To evaluate the patterns of antibodies produced by health care workers (HCWs) with SARS. Methods SARS antibodies were detected by ELISA among 505 blood samples from 20 HCWs with SARS and 445 HCWs without SARS in a hospital, and 75 healthy persons from community were chosen as control group. Results Among 20 HCWs who were clinically diagnosed as SARS, the positive rate of IgM was 35% (7/20), 4 of 5 and 3 of 9 HCWs had the positive antibodies after 3～4 and 5～8 weeks of the onset of SARS respectively, all 20 HCWs' IgM were negative after 9 weeks; the positive rate of IgG was 95% (19/20), 5 of 5, 10 of 10 and 19 of 20 HCWs' IgG were positive after 3～5, 6～9 and 18 weeks of the onset of SARS respectively. Among HCWs without SARS, the positive rate of IgM and IgG was 0 and 2.25% (10/445) respectively; the positive rate of IgM and IgG in 75 healthy persons was 0 and 1.33% respectively. Conclusion IgG positive rate in HCWs with SARS is high, there is no difference in the antibody positive rates between HCWs without SARS and healthy persons (P= 0.611), there is a possibility of latent infection among healthy persons.

关 键 词：SARS 医务人员 SARS抗体 酶联免疫吸附测定 

分 类 号：R181.32[医药卫生—流行病学]