胰岛素强化治疗继发失效的2型糖尿病的疗效观察  

作　　者：陈日秋[1] 季晓珍[1] 田江宣[1] 

机构地区：[1]浙江省丽水市人民医院内分泌科,323000

出　　处：《浙江临床医学》2005年第4期348-349,共2页Zhejiang Clinical Medical Journal

摘　　要：目的观察强化治疗对继发失效的2型糖尿病的疗效。方法对96例继发失效的2型糖尿病患者强化治疗前后分别予馒头餐试验,同步测定血糖、胰岛素和C肽,并计算胰岛素敏感性指数。结果强化治疗后的血糖明显改善,糖化血红蛋白(6.8±1.2%)显著低于治疗前(9.8±1.8%)(P<0.01),胰岛素敏感性指数增高,分别为-367±(-4.20)、-8.70±(-0.21)(P<0.01)。结论对继发失效的2型糖尿病患者要尽早给予胰岛素强化治疗,有助于降低葡萄糖毒性,部分恢复β细胞的功能。Objective To evaluate the effect of insulin intensive treatment on type 2 diabete smellitus(T 2DM) patients. Methods Bread testes were performed pro- and post- therapy in 92 T 2DM patients, and Blood glucose, serum insulin, C-peptide and sensitivity to insulin were analyzed. Results Post-treatment blood glucose improve obviously. Glycated ferrohemoglobin after insulin intensive treatment was lower than that before the treatment(P<0.01). Sensitivity to insulin were -367±(-4.20)、-8.70±(-0.21) respectively, and increased obviously(P<0.01). Conclusion Insulin intensive treatment performed in T 2DM early can reduce toxicity of glucose, and resume function of β-cell partially.

关 键 词：胰岛素强化治疗 继发失效 疗效观察 胰岛素敏感性指数 2型糖尿病患者 糖化血红蛋白 馒头餐试验 葡萄糖毒性 治疗前后 同步测定 治疗后 β细胞 血糖 

分 类 号：R587.1[医药卫生—内分泌] R749.3[医药卫生—内科学]