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机构地区:[1]广东医学院附属湛江中心人民医院,广东湛江524037 [2]中国人民解放军62医院,云南思茅665000
出 处:《中国临床药理学杂志》2005年第2期148-150,共3页The Chinese Journal of Clinical Pharmacology
摘 要:目的 研究焦虑、抑制对西沙必利药代动力学的影响。方法 用焦虑自评量表(SAS)和抑郁自评量表(SDS)测查并选出焦虑心理状态者8例和抑郁心理状态者8例,并设正常心理状态者8例为对照组。3组均口服西沙必利片15mg,每日1次。结果 焦虑心理状态较正常心理状态者,消除半衰期显著缩短,分别为(7. 56±0. 85), (8. 27±0. 91)h(P<0. 05);药-时曲线下面积显著减少,分别为(711. 54±49. 78), (741. 23±45. 65)μg·h·L-1 (P<0. 05)。抑郁心理状态较正常心理状态组的药代动力学参数相近。结论 焦虑心理状态者药物代谢加快,心理状态对西沙必利片的药代动力学有一定影响。Objective To study the effects of anxiety and depression status on pharmacokinetics of cisapride tablet. Methods The pharmacokinetics of 15 mg of cisapride tablet were studied in 8 cases with anxiety status and 8 cases with depression status screened by SAS and SDS questionnaire. Eight cases with normal psychological status were as control group. Results Compared with the normal group, the pharmacokinetic parameters of cisapride in 8 cases with anxiety status has changed, the elimination half-life was shorted from (8.27±0.91)h to (7.56±0.85) h(P<0.05) , AUC was decreased from (741.23±45.65) μg·L·h -1 to (711.54±49.78)μg·L·h -1 (P<0.05). However the parameters of 8 cases with depression status were similar to the normal group. Conclusion Anxiety might fasten the pharamcokinetics of cisapride.
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