二硫化碳对工人神经系统影响的研究  

Effects of carbon disulfide on nervous system function in the workers.

作　　者：陶宁[1] 毕勇毅[1] 谭晓东[1] 王福元[1] 

机构地区：[1]武汉大学公共卫生学院,武汉430071

出　　处：《华中医学杂志》2005年第2期108-109,118,共3页Central China Medical Journal

基　　金：比利时ABOS基金课题(No.13v13496)

摘　　要：目的　研究接触不同内外暴露水平二硫化碳(CS2)对工人神经系统的影响。方法　以某粘胶纤维工厂367 名接触CS25年以上的工人为调查组人群,进行了CS2对工人神经系统影响的横断面研究。以同厂135 名未接触CS2 的工人作为对照。结果　CS2可导致作业工人神经系统某些阳性症状发生的危险度较对照组明显升高。与对照组比较,高浓度接触组双侧下肢温度觉障碍发生的相对危险度增加(左侧:OR=5.04;右侧:OR=3.82);低浓度组的运动神经近、远端动作电位波幅降低(近侧:r1=-0.83;远侧:r2=-1.38),F波最短潜伏期延长(r=2.03),高浓度组较低浓度组的F波最短潜伏期延长(r=1.87)。结论　接触CS2 工人的神经系统症状明显升高。尿TTCA含量可作为CS2 接触工人的一项敏感的内暴露指标。Objective To study the effect of different internal and external exposure levels of CS 2 on nervous system of workers.Methods A cross-sectional study was carried out in a viscose factory. The exposure group included 367 workers whose exposure time was over 5 years in the viscose industry exposed to CS 2 . The control group included 135 employees from the same factory but without occupational contact with CS 2 .Results The odds ratio (OR) of some complains was significantly increased in workers exposed to CS 2 . The OR of sensitivity temperature disturbance in low extremity was significantly increased (left leg: OR= 5.04 ; right leg: OR= 3.82 ) in high level exposed group as compared with control group. Binary evaluation (comparison of exposed persons versus controls) revealed a lower value in the exposed group for the amplitude after stimulating at the proximal (pma) and distal (dma) of motor nerve (pma: r 1 = -0.83 ; dma: r 2 = -1.38 ), and a prolonged minimum latency of F wave (r= 2.03 ). Comparison of the high and low level exposure groups revealed that the minimum latency of F-wave was significantly prolonged in high level exposed persons (r= 1.87 ).Conclusion The complaints of nervous system are significantly increased in exposed group as compared with control group. The TTCA content in urine can acts as a sensitive internal exposure parameter for Chinese workers exposed to CS 2 .

关 键 词：二硫化碳 神经系统 神经传导 内暴露 

分 类 号：R131[医药卫生—劳动卫生]