N-甲基-2-吡咯腈的合成改进  

Improved synthesis of N-methyl-2-pyrrolecarbonitrile

作　　者：梁志宏[1] 赵林[1] 马步伟[2] 赵振新[2] 原思国[1] 

机构地区：[1]河南省精细化工重点实验室,河南郑州450002 [2]平顶山工学院,河南平顶山467001

出　　处：《信阳师范学院学报（自然科学版）》2005年第2期192-194,共3页Journal of Xinyang Normal University(Natural Science Edition)

基　　金：河南省杰出人才创新基金资助项目(0121001600)

摘　　要：以N 甲基吡咯(NMP)为起始原料,先与Vilsmeier试剂反应,经碳酸钠水解、二氯乙烷萃取制得N 甲基 2 吡咯醛(NMPA),此法溶剂回收利用率高、安全、易于工业化生产并降低了生产及污水处理费用 再以NMPA与盐酸羟胺经肟化制得N 甲基 2 吡咯肟(NMPAO),最后在醋酐中脱水制得N 甲基 2 吡咯腈 (NMPC) 在由NMPAO脱水制NMPC的过程后,经氢氧化钠水溶液中和,降低了体系的色度,萃取易于进行,产品收率74. 7%N-methyl-2-pyrrolealdehyde was synthesized by the reaction of N-methylpyrrole with Vilsmerier reagent and by hydrolysis in Na_2CO_3 solution subsequently. Owing to Na_2CO_3 and dichloroethane instead of CH_3COONa and ether, the reformative process has effective solvent recovery and high security. After then, N-methyl-2-pyrrolecarbonitrile(MPC) was synthesized by oximation and dehydration of N-methyl-2-pyrrolealdehyde in hydroxylamined hydrochloride and acetic anhydride respectively. By neutralization of reaction system with NaOH solution,its colourity was decreased, the following extraction operation was convenient, and the yield of MPC is (74.7%.)

关 键 词：吡咯腈 N-甲基吡咯 合成 

分 类 号：TQ251.3[化学工程—有机化工]