药物单克隆抗体的制备及在药物分析中应用  

The Production and Application of Anti-drug Monoclonal Antibodies

作　　者：杨金娥[1] 袁宗辉[1] 

机构地区：[1]华中农业大学畜牧兽医学院兽药研究所,湖北武汉430070

出　　处：《江西农业大学学报》2005年第2期305-308,共4页Acta Agriculturae Universitatis Jiangxiensis

基　　金："九五"国家重点科技攻关项目(96-005-02-04-04)

摘　　要：概述了药物(含激素类药物)半抗原合成人工免疫原方法以及采用B-淋巴细胞杂交瘤技术制备药物单克隆抗体的要点,着重介绍了药物单克隆抗体作为几种免疫分析方法的核心试剂,在临床药理学研究及生物样品的药物残留分析中的应用,并对其进行了评述,以期了解药物单克隆抗体的应用现况及前景。The methods and principles for the preparation of drug-protein conjugates as immunogen and the main points of producing anti-drug monoclonal antibodies with B-lymphoblasts hybridoma technique are introduced briefly in this paper. The application of anti-drug monoclonal antibodies is reviewed in the fields of clinical pharmacology, and some comments about the methods are also given here.

关 键 词：药物单克隆抗体 制备 药物免疫分析 应用 

分 类 号：S852.4[农业科学—基础兽医学]