几种药物对电针镇痛作用和鼠脑细胞游离钙浓度的影响  

Effect of Some Drugs on Electroacupuncture Analgesia and Cytosolic Free Ca^(2+) Concentration of Mice Brain

作　　者：胡洁[1] 谢吉民[2] 胡继岳[2] 张宇[3] 王金晞[3] 陈荣三[3] 

机构地区：[1]镇江医学院附属医院 [2]镇江医学院,镇江212001 [3]南京大学配位化学国家重点实验室,南京210008

出　　处：《针刺研究》1994年第1期55-58,共4页Acupuncture Research

摘　　要：本文研究了延胡索、白芷和安乃近对电针镇痛作用的影响，同时用荧光染料Fura－2和AR－CM阳离子测定系统测定了小鼠下丘脑（HT）及导水管周围灰质区（PAG）细胞内的游离钙浓度（[Ca2+]i）。结果表明延胡索能明显增强电针的镇痛作用，在电针和延胡索镇痛时小鼠两脑区的（[Ca2+]i）均降低（与对照组比较，P＜0．01）。在同样条件下，白芷和安乃近组的[Ca2+]i）与对照组比较无显著差异，揭示其镇痛作用机理与电针和延胡索可能不同。In this paper, the effects of some analgesic drugs such as corydalis yanhusuo, Angelica dahurica and Analginum on electroacupuncture analgesic function were studied. In the meantime, the concentrations of cytosolic free Ca2+ ([Ca2+]i) in mice hypothalamus (HT) and periaqueductual grey (PAG)were determined by use of the fluorescence dye Fura-2/AM and AR-CM cation measurement system.The results showed that Corydalis yanhusuo obviously strengthened the analgesic function produed by electroacupuncture. Besides, the [Ca2+]i in the two brain regions of mice in these analgesic experiments with electroacupuncture and Corydalis yanhusuo were all decreased (compared with saline control group, P<0. 01), In the same experimental condition, the [Ca2+]i in Angelica dahurica group and Analginum group has no significant difference compared with the control group, the analgesic mechanisms may be different from that of electroacupuncture and Corydalis yanhusuo

关 键 词：电针 镇痛 胞浆游离 钙离子 镇痛药 

分 类 号：R245.97[医药卫生—针灸推拿学]