微电泳阿托品削弱脑刺激对束旁核神经元伤害性反应的抑制作用  

Iontophoretic Atropine Attenuates the Inhibitory Effect of Stimulating SmI on Nociceptive Responses of pf Neurons

作　　者：徐志卿[1] 徐维[1] 陈正秋[1] 

机构地区：[1]中国中医研究院针灸所,北京100700

出　　处：《针刺研究》1994年第1期16-19,共4页Acupuncture Research

摘　　要：本文用多管微电极方法，记录大鼠束旁核神经元放电，观察微电泳阿托品时刺激SmⅠ区对Pf神经元伤害性反应的影响，结果表明：1．微电泳导入阿托品同时电刺激SmⅠ区，见到脑刺激对Pf神经元伤害性反应的抑制作用被减弱；2.微电泳导人ACh可明显减弱Pf神经元的伤害性反应。上述结果揭示，ACh可作为神经递质参与皮层下行性痛调制过程。Using the techniques of multimicropipette and iontophoresis, we observed whether ACh was involved in the cortical descending modulation of Pf neurons in rats. It was shown that the inhibition elicited by stimulation of the sensorimotor area (SmⅠ) was attenuated after microiontophretic atropine and that the nociceptive responses of Pf neurons were obviously reduced by microiontophoretic ACh.Therefore, it suggests that ACh may be considered as one of the neurotransmitters involved in the descending modulation of pain

关 键 词：微电泳 脑刺激 束旁核 乙酰胆碱 

分 类 号：R245－0[医药卫生—针灸推拿学]