针刺镇痛过程中谷氨酸参与体感Ⅱ区经运动皮层对丘脑髓板内核群的下行调节  

Involvement of Glutamate in Corticofugal Modulation of Intralaminar Nuclei from SⅡ Via Motor Cortex in Acupuncture Analgesia

作　　者：郑欣[1] 陈正秋[1] 徐维[1] 石宏[1] 

机构地区：[1]中国中医研究院针灸所,北京100700

出　　处：《针刺研究》1994年第1期11-15,共5页Acupuncture Research

摘　　要：本实验以皮层表面局部给药及玻璃微电极细胞外记录丘脑髓板内核群（ILN）神经元单位放电的方法观察针刺镇痛过程中谷氨酸（Glu）是否参与体感Ⅱ区（SⅡ）经运动波层（MCtx）对丘脑ILN神经元的下行调节。结果表研：MCtx局部施予谷氨酸二乙酯（GDEE）可减弱刺激SⅡ及电针对ILN神经元伤害性反应的抑制效应。提示：Glu是SⅡ经MCtx对ILN实行调控的递质之一;电针可能通过激活SⅡ向MCtx释放Glu参与对ILN的调节。The present experiments were designed to study the effect of glutamate on cortical somatosensory area Ⅱ (S Ⅱ) producing descending modulation of intralaminar nuclei (ILN) via the motor cortex (MCtx) in acupuncture analgesia. The glutamate antagonist glutamate diethylester (GDEE) or saline was topically applied at MCtx in 17 cats. Single unit activities of ILN neurons were extracellularly recorded. The results were as follows:1. The nociceptive responses of ILN neurons were attenuated by stimulating S Ⅱ after topical administration of saline at MCtx. However, The inhibitory effect of stimulating S Ⅱ in the same neurons was reduced after application of GDEE. There was a significant difference at 0′ - 1′ after the stimulation between the two groups (n = 10, P<0. 05).2. The inhibitory effect of electroacupuncture (EA) on nociceptive responses was reduced after topical application of GDEE, while marked inhibition was shown at 0′- 10′ after cessation of EA in the saline control group (n=11, P<0. 05).The results, together with the finding that the majority of S Ⅱ neurons could be activated by EA, showed that glutamate released from S Ⅱ to MCtx might be involved in corticofugal modulation of ILN from S Ⅱ via MCtx in acupuncture analgesia

关 键 词：髓板内核群 谷氨酸 针刺镇痛 

分 类 号：R246.9[医药卫生—针灸推拿学]