损毁大鼠大脑皮层体感Ⅱ区导致电针对中缝大核痛调制的效应减弱  

The Lesion of Somatosensory Area Ⅱ of Cerebral Cortex Reducing the Effects of Electroacupuncture of "Zusanli" on Nucleus Raphe Magnus in Rats

作　　者：蒋旻春[1] 刘乡[1] 

机构地区：[1]中国中医研究院针灸研究所,北京100700

出　　处：《针刺研究》1994年第1期4-7,共4页Acupuncture Research

摘　　要：以往曾证明刺激皮层体感Ⅱ区（SmⅡ）可以激活具有下行痛调制机能的中缝大核（NRM），神经元自发放电增多，伤害性反应受到抑制，而且刺激SmⅡ的这种效应与电针“足三里”所引起的效应成正相关关系（P＜0．001），表明两者有某种共同中枢机制。本文的工作进一步证明电解损毁SmⅡ区，可削弱电针“足三里”激活NRM神经元和抑制伤害性反应的作用。表明SmⅡ区参与电针镇痛，它的结构和机能的完整是电针镇痛所必须的，但不是唯一的结构。因SmⅡ损毁后电针的镇痛效应并未完全消失，可能还可通过其它中枢结构，参与内源性镇痛系统的作用，而产生一定的镇痛作用。This work was to study the influence of lesion of Sm Ⅱ on effects of electroacupuncture (EA) upon nucleus raphe magnus (NRM).The experiments were performed on rats. The unit discharges of NRM neurons and their responses to noxious stimulation on tail tip were recorded extracellularly with glass microelectrode.The excitatory neurons of NRM were chosen and divided into two groups, one of them(n=10)was control before lesion of bilateral Sm Ⅱ and another (n=17) after lesion, two neurons of this group were also observed before lesion. It was found that the neurons in the contral group before lesion of sm Ⅱ could be activated by EA of 'Zusanli', the increase of spontaneous diacharges in 0-10 minutes and the 20th minute, and the decrease of their nociceptive responses in 0-25 minutes were statistically significant (P<0. 05-0. 001).But in the group after lesion the neurons were not obviously activated by EA of 'Zusanli'. The difference of the spontaneous discharges between the two group was statistically significant in 0-10 minutes (P<0.05-0.001), the nociceptive reponses in 0-10 minutes and at the 20th minute (P<0. 05-0.001).The results show that integrity of Sm Ⅱ is important to acupuncture analgesia, and further suggest that information from EA of 'Zusanli' could arrive at Sm Ⅱ at least partially, and then activate NRM inducing analgesia

关 键 词：中缝大核 针刺镇痛 SmⅡ 

分 类 号：R246[医药卫生—针灸推拿学]