艾灸对多药抗药基因产物P-170糖蛋白功能的影响  

Effects of Moxibustion on the Function of MDR Gene Product, P-Glycoprotein (P-170)

作　　者：张霆钧[1] 高翠华[1] 郭莹[1] 

机构地区：[1]中国中医研究院针灸研究所,北京100700

出　　处：《针刺研究》1994年第2期69-71,共3页Acupuncture Research

基　　金：国家自然科学基金

摘　　要：利用我们建立的S－180抗阿霉素抗药细胞荷瘤BABL／c小鼠，艾灸关元穴可对多药抗药基因产物（P－170）糖蛋白泵出药物功能有微弱的抑制。艾灸能显著增加钙通道抑制剂异博定对泵出药物功能的抑制作用，这种作用只在允许药物剂量范围才显示出来，当剂量大于允许范围时，效果就不明显。此研究不仅为从分子水平探索针灸的作用机理研究开拓新途径，而且在临床上对克服化疗中的抗药性具有应用前景。The experiments were performed on BABL/c mice with S-180R adriamycin resistant tumor cells. This animal model was used to analyze the drug accumulation in the S-180R cells by flow cytometer. The drug accumulation presents the pump activity of multidrug resistance (MDR) gene product P-glycoprotein (P-170) in the cell memberane, A weak inhibition was found when moxibustion at Guan-Yan point alone. And a very significant inhibition was observed in the presence of lowdosageof verapanlil, but not at high dose. This study may develop a new way to research the mechanism of actlpuncture and moxibustion at molecular level,and may be useful to overcome the anticancer drug resistance.

关 键 词：针灸疗法 多药抗药性 P-170 糖蛋白 艾灸 

分 类 号：R245.81[医药卫生—针灸推拿学]