运动皮层局部降温对刺激体感Ⅱ区抑制丘脑髓板内核群神经元伤害性反应的影响  

Influence of Cooling Motor Cortex on the Inhibitory Effect of Stimulation of SII on Nociceptive Responses in ILN Neurons

作　　者：郑欣[1] 陈正秋[1] 徐维[1] 石宏[1] 

机构地区：[1]中国中医研究院针灸所,北京100700

出　　处：《针刺研究》1994年第2期21-25,共5页Acupuncture Research

基　　金：国家自然科学基金

摘　　要：本实验以MCtx局部降温及玻璃微电极细胞外记录ILN神经元单位放电的方法观察SII对ILN的下行调节是否有MCtx的参与.结果表明MCtx局部降温（19℃～20℃）可减弱刺激SII对ILN神经元伤害性反应的抑制效应；当MCtx局部温度降至17℃～18℃时，刺激SII的抑制效应几乎被取消。提示SII对ILN的下行调节部分通过MCtx实现。Fibers from the cortical somatosensory area Ⅱ (SII) or motor cortex (MCtx) to intralaminar nuclei (ILN) have been proven to exist, and SII was found to be connected with MCtx by cortico-cortical fibers. The present work was undertaken to study whether MCtx participated in SII producing descending mdulation of ILN.All experiments were performed on sodium pentobarbitone anaesthetised cats. Single unit activities of ILN neurons were extracellularly recorded by glass microelectrodes. The effects of stimulating SII on nociceptive responses of ILN neurons were observed before and after cooling MCtx. The nociceptive responses of ILN neurons were attenuated by stimulating SII. There was a statistically significant difference at 0' - 2' after the stimulation (n= 14, P<0.05). The inhibitory effect of stimulating SII was reduced after cooIing MCtx (19℃ - 20℃) in 8 neurons, and abolished in other neurons when the temperature was below 18℃.MCtx was involved in SII producing descening modulation of ILN.

关 键 词：丘脑髓板内核群 伤害性反应 运动皮层 针刺镇痛 

分 类 号：R245[医药卫生—针灸推拿学]