111例双黄连过敏反应文献分析  

Literature analysis of allergic reactions associated with Shuanghuanglian in 111 cases

作　　者：张跃文[1] 时莉锋 李建平[1] 王守东[1] 方晓艳[1] 白明[1] 常黎明 

机构地区：[1]河南中医学院,河南郑州450008 [2]郑州市上街人民医院,河南郑州450041 [3]焦作市药检所,河南焦作454000

出　　处：《药物不良反应杂志》2005年第2期100-103,共4页Adverse Drug Reactions Journal

摘　　要：目的:分析临床应用双黄连引致的过敏反应的规律。方法:对2000年1月-2004年3月中国期刊网中收录的111例双黄连过敏反应在性别、年龄、发生时间、给药途径和临床表现进行分析。结果:双黄连过敏与年龄、性别无关,与给药途径有关,注射剂易发生过敏反应。该药过敏的临床表现有:过敏性休克67例(60%),皮肤黏膜症状61例(55%),其他类型过敏反应14例(13%)31例同时出现多种过敏症状。过敏发生时间最短为开始用药1m in以内,最长为用药后72h,97例(87%)在用药过程中发生过敏症状。结论:双黄连的过敏反应以速发型过敏反应(如过敏性休克)为主,应是临床关注的重点。Objective: To analysis allergic reactions caused by Shuanghuanglian in clinical practice. Methods: 111 cases with allergy due to Shuanghuanglian were collected and analysed from 'China Periodicals Net'(2000.12-2004.3). Results: It was shown that Shuanghuanglian-induced allergy was not related to sex and age of patients but related to route of admi-nistration. As for the types of allergy 67 were anaphylactic shock (accounting for 60 %) 61 skin reactions (55 %) 14 the other reactions (13%) and 31 suffered more than one symptoms of allergy. Shuanghuanglian-induced allergy occurred from one minute to three days after administration of the drug and 97 cases (87%) developed the symptoms of allergy in the period of treatment. Conclusion: Immediate hypersensitivity reaction (such as anaphylactic shock)is the common type of allergy associated with Shuanghuanglian.

关 键 词：双黄连 过敏反应 

分 类 号：R286[医药卫生—中药学]