丹参葡萄糖注射液对大鼠急性心肌缺血的保护作用  

Danshen glucose injection protection against experimental myocardial ischemia of rats

作　　者：丁伯平[1] 杨解人[1] 熊莺[1] 陈国祥[1] 

机构地区：[1]皖南医学院药理教研室,安徽芜湖241001

出　　处：《中成药》2005年第4期438-441,共4页Chinese Traditional Patent Medicine

摘　　要：目的:观察丹参葡萄糖注射液iv对两种不同实验性大鼠急性心肌缺血模型的保护作用。方法:采用结扎法和垂体后叶素iv造成大鼠急性心肌缺血模型,观察心电图变化、血流动力学和形态学指标。结果:本药以 4. 0g·kg-1, 8. 0g·kg-1的剂量给大鼠静注,对结扎冠脉左前降支 30min所致缺血再灌注模型,有恢复心率、血压、左室舒张末期压、左室内压及其最大上升、下降速率(±dp/dtmax)和心电图ST段的作用;亦能显著缩小冠脉结扎大鼠的心肌梗死面积;对静脉注射垂体后叶素所致急性心肌缺血模型,有逆转ST段偏移与T波降低的保护作用。结论:丹参葡萄糖注射液对实验性大鼠急性心肌缺血具有保护作用和治疗作用。AIM: Two models of experimental myocardial ischemia were set up to observe the protection of Danshen glucose injection against ischemia in rats. METHODS: Models of experimental acute myocardial ischemia were made by ligature or medication (pituitrin) to check the indices of ECG, hemodynamics, and morphology. RESULTS: A dosage of Danshen glucose injection 4.0 g/kg, 8.0 g/kg was given to rats by intravenous injection; the rats had undergone a thirty-minute ligatute of coronary left anterior descending branch, and used as a model of ischemic reperfusion. The observations showed that Danshen glucose injection exerted a recovery effect on heart rate, blood pressure, internal pressure of left ventricule and its peak/trough rate (±dp/dt max ), and ST segment (electrocardiogram). The injection markedly reduced the myocardial infarct size of the coronary-ligatured rats. The injection benefited the rats with pituitrin (iv) induced acute myocardial ischemia to reverse and T-wave fall. CONCLUSION: Danshen glucose injection has a protective and therapeutic action on the experimental myocardial ischemia of rats.

关 键 词：心肌缺血 丹参注射液 大鼠 

分 类 号：R285.5[医药卫生—中药学]