生物组织光学参数的校准模型及测量  

Phantoms with Tissue-Like Optical Properties for Use in Near-InfraredSpectroscopy and Imaging

作　　者：赵军[1] 丁海曙[1] 赵忠耀[2] 杜鹃[2] 

机构地区：[1]清华大学生物医学工程系,北京100084 [2]宾夕法尼亚大学生物化学生物物理系,美国费城pa19104

出　　处：《光电子．激光》2005年第4期496-500,共5页Journal of Optoelectronics·Laser

摘　　要：在intralipid 墨水(ink)液体模型中,通过改变intralipid溶液和墨水的浓度就可以灵活地获得不同的光学参数。制作了一种可以长期重复使用的光学特性稳定的Si树脂模型,它是利用TiO2 粉末作为散射颗粒,同时加入C粉颗粒来改变模型的吸收特。为了验证intralipid 墨水液体模型制作中基于Mie散射理论的近似计算公式,利用多波长的时间分辨(TRS)方法对不同intralipid浓度的液体模型进行了测试。实际测量结果和Mie散射理论计算的误差在5%以内,这可能是由于所作用的intralipid溶液之间的差别造成的。利用频域的相位调制系统(PMD)对Si树脂模型进行了多间距测量,斜率的线性回归拟合结果显示了良好的线性度(R2>0.99),从而保证了光学参数测量结果的准确性。Intralipid was used for providing the scattering component in a liquid tissue phantom. By diluting intralipid we are able to change the scattering properties of our model. Addition of India ink changes the model absorption. In order to provide a stable and reproducible phantom, a pliable RTV silicon resin model was developed. Titanium oxide and carbon black powders were added to the resin to obtain tissue-like optical properties. Time-resolved spectroscopy (TRS) was employed to obtain experimental values for reduced scattering coefficient for intralipid-ink solution at various wavelengths and we compare these values with those predicted by Mie theory. The 5% difference between our results and the results from Mie thoery is attributed at least in part to a difference in intralipid composition. Good linearity (R2>0.99) is found for the lines used to define the slope of AC component and phase.

关 键 词：生物组织 MIE散射理论 校准 TiO2粉末 近似计算公式 光学参数测量 树脂模型 光学特性 散射颗粒 模型制作 时间分辨 理论计算 实际测量 调制系统 回归拟合 体模型 墨水 多波长 线性度 准确性 浓度 溶液 Si 液体 

分 类 号：O436.2[机械工程—光学工程] Q631[理学—光学]