花椒毒酚对离体豚鼠心房肌的钙拮抗作用  

Calcium Antagonistic Effect of Xanthotoxol on Isolated Guinea Pig Atria

作　　者：刘建新[1] 连其深[1] 周俐[1] 周青[1] 何蔚[1] 朱遵平[1] 赖飞[1] 

机构地区：[1]赣南医学院药理教研室,江西赣州341000

出　　处：《中药材》2005年第4期319-321,共3页Journal of Chinese Medicinal Materials

基　　金：江西省科技厅科技计划资助项目 (No 20021031001 );江西省教育厅科学技术研究项目(赣教计字 2000 254号)

摘　　要：目的:研究花椒毒酚(XT)抑制豚鼠心肌收缩力的作用机理。方法:采用张力描记法测定离体豚鼠左房肌的收缩力。结果:XT明显抑制豚鼠左房肌的正阶梯现象和静息后增强效应。钙通道阻滞药维拉帕米对正阶梯现象的抑制作用较XT为强,并可使正阶梯现象翻转,但对静息后增强效应无明显影响。XT对哇巴因的正性肌力作用及随后出现的心肌收缩力降低的毒性反应均有明显的对抗作用。结论:XT通过阻滞豚鼠左房肌的电压依赖性和受体调控性钙通道而发挥抑制心肌收缩力的作用。Objective: To study the mechanism of depressant effect of xanthotoxol(XT) on contractility in the isolated guinea pig atria. Methods: The contractile force of the isolated left atria was determined by tension recording method.Results: In the experiments on contractility of the left atria XT and Verapamil(Ver) significantly depressed the positive staircase phenomena, which was reversed by Ver but not by XT. However, the post-rest potentiation of myocardial contraction in the left atria was only markedly decreased by XT but not by Ver. Furthermore, XT not only attenuated the positive inotropic action, but also delayed the following toxicity response induced by ouabain in the isolated left atria. Conclusion: XT blocked not only the voltage dependent calcium channel, but also the receptor operated calcium channel in the isolated guinea pig atria.

关 键 词：花椒毒酚 钙拮抗作用 豚鼠心房肌 静息后增强效应 心肌收缩力 正阶梯现象 钙通道阻滞药 正性肌力作用 电压依赖性 作用机理 离体豚鼠 抑制作用 维拉帕米 对抗作用 毒性反应 对哇巴因 左房 描记法 调控性 

分 类 号：R285.5[医药卫生—中药学] R972.2[医药卫生—中医学]