新生儿缺氧缺血性脑病早期干预临床研究  

The Clinical Study of Early Meddle in Newborn HypoxicIschemic Encephalothy

作　　者：徐晓颖[1] 何冬若[1] 薛丽馥[1] 修建华[1] 金晓秋[1] 张英慧[1] 

机构地区：[1]黑龙江省齐齐哈尔医学院第二附属医院儿科神经电生理室,161006

出　　处：《医学研究通讯》2005年第4期49-50,共2页Bulletin of Medical Research

摘　　要：目的为了更有效治疗新生儿缺氧缺血性脑病(HIE),降低神经系统后遗症的发生。方法将中、重度 HIE 分为干预组48例和对照组30例,对干预组于新生儿期及新生儿期后给予高压氧及神经生理学训练。用 NBNA、DQ、脑地形图对治疗效果评估。结果比较两组14～16天、26～28天 NBNA 值干预组高于对照组(P<0.05),脑地形图显示异常率对照组高于干预组,DQ 值干预组高于对照组(P<0.05)。结论婴儿期是中枢神经系统发育最迅速,可塑性最强,代偿能力最好的脑发育关键时期。所以早期干预是从新生儿期开始延续至新生儿期后甚至幼儿期,是治疗 HIE 行之有效的方法,降低了中、重度 HIE 神经系统后遗症的发生。Objective To treat newborn hypoxic ischemic encephathy effectinely(HIE),decrease sequelas innervous system.Methods Se- lecting 78cases with middle and serious hypoxic ischemic encephathy effectinely to divided into meddle group(48)and control group(30).The hyperbaric oxygen and neurophysiology trainingwere given to meddle group,in nemborn and postnewborn stages.To value curative effect with NBNA,DQvalue,and electroencephalogram.Results The meddle group compare with control group NBNA value was higher in 14～16 days and 26～28 days significante(P<0.05).The abnormat rate of electroencephalogram in control group was higher than in meddle group,the DQ value in meddle group was higher than in control group(P<0.05).Conclusions the infant stage is key stage that the development is the rapi- dest,the plasticity and the compensatory capability are the strongest in central nervous system,the early meddle is start fyom newborn stage to in- fant stage,and is effective curative method to cura HIE and decrease sequelas in nervous system of middle and serious hypoxic ischemic en- cephathy.

关 键 词：新生儿缺氧缺血性脑病 早期干预 临床研究 神经系统后遗症 中枢神经系统发育 神经生理学训练 重度HIE 新生儿期后 脑地形图 对照组 有效治疗 NBNA 效果评估 关键时期 代偿能力 高压氧 异常率 DQ值 婴儿期 可塑性 脑发育 

分 类 号：R722.12[医药卫生—儿科] R338.2[医药卫生—临床医学]