儿童1型糖尿病环境危险因素病例对照研究  

Case-control study on environmental risk factors of type 1 diabetes in Shanghai population

作　　者：任宏[1] 欧阳凤秀[1] 罗飞宏[2] 沈水仙[2] 姜庆五[1] 

机构地区：[1]复旦大学公共卫生学院,上海200032 [2]复旦大学附属儿科医院

出　　处：《中国公共卫生》2005年第2期129-130,共2页Chinese Journal of Public Health

基　　金：国家自然科学基金项目 (30 1 70 81 8) ;上海市卫生局资助项目

摘　　要：目的　探索 1型糖尿病的环境危险因素。方法　采用 1∶4病例对照研究的方法。选择 2 0 0 3年 5月～ 1 2月在复旦大学附属儿科医院内分泌病房住院或者门诊随访的上海地区 1型糖尿病患儿 4 0例 ,配以 1 6 0例从上海市社区人群中选取的未患 1型糖尿病、身体健康的儿童为对照。使用单因素和多因素条件Logistic回归模型进行分析。 结果　多因素条件Logistic回归分析结果显示 ,儿童时期的感染、母亲孕期的被动吸烟史和孕期感染史与 1型糖尿病的发生密切相关 (P <0 0 5 ) ,OR值分别为 9 399,2 2 36 1和 1 2 833。结论　儿童时期的感染、母亲孕期的被动吸烟史和孕期感染史是儿童 1型糖尿病的重要环境危险因素。Objective To explore the environmental risk factors of type 1 diabetes in Shanghai. Methods 1∶4 matched case control study was used to carry out this investigation.Cases were forty children with type 1 diabetes who were in hospital or clinic follow-up in endocrine division in Children's Hospital Fudan Medical Unviersity from May to December,2003.Controls were one hundred and sixty normal children selected from community in shanghai.Univariate and multivariate conditional Logisitic regression was used to analyze the database.Results Results of the multiivariate conditional Logisitic regressive analysis showed children's infection,passive smoking and infection in pregnancy had significant relationship with type 1 diabetes;the odds ratios were 9.399,22.361and 12.833 respectively.Conclusion children's infection,passive smoking and infection in pregnancy were environmental risk factors of type 1 diabetes

关 键 词：1型糖尿病 环境危险因素 病例对照研究 

分 类 号：R587.1[医药卫生—内分泌]