宫内铅暴露对大鼠神经行为发育的影响  

Effect of low-level lead exposure in uterus on neurobehavioral development of rats

作　　者：胡前胜[1] 任铁玲[1] 傅洪军[1] 董胜璋[1] 陈学敏[2] 

机构地区：[1]中山大学公共卫生学院预防医学系,广州510080 [2]华中科技大学同济医学院公共卫生学院

出　　处：《中国公共卫生》2005年第2期152-153,共2页Chinese Journal of Public Health

基　　金：国家自然科学基金部分资助 (30 2 71 1 0 9;30 371 1 98)

摘　　要：目的　研究低水平宫内铅暴露对Wistar大鼠早期行为及学习记忆等神经行为发育的影响。方法　雌性大鼠分别经 0 5 ,1 0和 2 0mmol/LPbCl2 暴露后 ,观察其F1代仔鼠断崖回避、平面翻正、前肢悬挂、空中翻正、听觉惊愕和视觉定位等早期行为发育以及应用水迷宫、Y迷宫检测仔鼠学习记忆能力。结果　孕鼠经 2 0mmol/LPbCl2 染毒后 ,其仔鼠听觉惊愕和视觉定位等行为指标的发育出现了延迟 ;而 1 0和 2 0mmol/LPbCl2 染毒后的孕鼠 ,导致其仔鼠的空中翻正发育延迟 ,仔鼠的空间方位辨别学习能力和运动学习能力、短时记忆和长时记忆能力的损害。结论　宫内低水平铅暴露具有较强的行为发育毒性。Objective To study the impact of low-level lead exposure in uterus on the neurobehavioral development of rats. Methods Female Wistar rats were exposed to PbCl\-2 at dosage of 0.5,1.0 and 2.0mmol/L respectively,and their F1 pups were examined to observe the impact of lead on the early behavioral development such as cliff avoidance,surface righting,forelimb hanging,air righting,acoustic startle and visual placing.Water maze test and Y maze test were also done to detect the impact of lead on the development of learning and memory of rat pups.Results 2.0mmol/L PbCl\-2 exposed in uterus caused the F1 Wistar rat pups'visual placing and acoustic startle development delaying;exposed to 1.0 and 2.0mmol/L PbCl\-2 in uterus,the pups'air righting were delayed and their learning and memory abilities were impaired.Conclusion Low-level lead exposure in uterus impaired the neurobehavioral development of rats significantly.

关 键 词：神经行为 发育毒性 学习记忆 铅 

分 类 号：R994.7[医药卫生—毒理学]