药物对接振家兔周围血管及神经功能的影响  

Effects of drug intervention on functions of periphery vascular and periphery nerves in rabbits exposed to vibration

作　　者：林立[1] 王彦英[2] 张璟[1] 刘云儒[1] 

机构地区：[1]济宁医学院预防医学系职业卫生与环境医学研究所,济宁272013 [2]济宁医学院附属医院

出　　处：《中国公共卫生》2005年第2期171-172,共2页Chinese Journal of Public Health

基　　金：山东省自然科学基金资助 (Y 2 0 0 2c 2 0 )

摘　　要：目的　探讨药物干预对接振家兔血管内皮活性物质及周围神经传导功能的影响。方法　对接振家兔分别给予L -精氨酸、卡托普利干预 ,并进行干预前后血浆内皮素 (ET)、一氧化氮 (NO)、坐骨神经运动传导速度、远端潜伏时的测定与分析。结果　与对照组比较 ,单纯接振组接振后上述指标变化差异有统计学意义 (P <0 0 1 ) ;L -精氨酸干预组和卡托普利干预组上述指标与试验前及对照组比较 ,差异无统计学意义。结论　L -精氨酸和卡托普利能够改善接振家兔周围血管及神经的功能。Objective To study the effects of drug intervention on the functions of periphery vascular and periphery nerves in rabbits exposed to vibration. Methods Rabbits were divided into one vibration group,two drug-intervention groups and one control group randomly.The concentration of plasma nitric oxide(NO),endothelin(ET)and the nerve conduction function were measured and analyzed before and after vibration loading test(VLT)in each group.Results Compared with the control group,the concentration of plasma nitric oxide(NO),endothelin(ET)and the nerve conduction function had a significant change in vibration group,but a little change in drug-intervention groups.Conclusion L-Arginine and captipril can improve the functions of periphery vascular and periphery nerves of rabbits exposed to vibration.

关 键 词：局部振动 药物干预 血管内皮活性物质 周围神经 

分 类 号：R135.4[医药卫生—劳动卫生]