亚低温治疗对颅脑损伤颅内压及脑氧代谢影响的临床意义  

The Study of Moderate Hypothermia that Affects the ICP and Brain tissue PbrO_2 in Head Injury and the Deportment of Neurosurgery

作　　者：林源泉[1] 贾军[1] 刘文锋[1] 张浚[1] 

机构地区：[1]广东省深圳市龙岗中心医院神经外科,518116

出　　处：《齐齐哈尔医学院学报》2005年第3期244-245,共2页Journal of Qiqihar Medical University

摘　　要：目的探讨重型脑损伤患者亚低温(33～35℃)治疗前后颅内压(ICP),脑组织氧分压(PbrO2)的变化及临床意义。方法32例重型颅脑损伤患者分为亚低温组及对照组,放置ICP脑组织PbrO2光纤探头,持续监测ICP及脑组织PbrO2。结果亚低温治疗24h后ICP逐渐下降,脑组织PbrO2逐渐上升,与对照组比较差异有显著性(P<0.05)。结论亚低温治疗能明显降低重型颅脑损伤患者ICP,改善脑组织氧代谢。降低患者死亡率及致残率。Objective To probe the alteration and significance intracranial press(ICP)and brain tissue PO 2(PbtiO 2) in severe head injury treated by moderate hypothermia(33~35℃).Methods 32 cases of severe head injury were randomly divided into moderate hypothermia group and control group.All cases were put ICP and PbtiO 2 probes into cerebral cortex,and continually monitored the ICP and PbtiO 2.Results in moderate hypothermia group the ICP gradually descended after 24 hours,and the PbtiO 2.gradually ascended.There was obvious difference between two groups (P<0.05).Conclusions The therapy of moderate hypothermia in severe head injury can obviously descend ICP,reform brain tissue oxygen metabolism,lower death rate and disablement rate.

关 键 词：亚低温治疗 颅脑损伤 颅内压 脑氧代谢 

分 类 号：R651.15[医药卫生—外科学]