慢性阻塞性肺疾病患者急性发作期痰白细胞介素-8及白细胞介素-17测定的意义  

Significance of Detecting Interleukin-8 and Interleukin-17 in Sputum from Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：曾宪升[1] 何家富[1] 阮淑芬[1] 

机构地区：[1]湖北省襄樊市中心医院呼吸内科,襄樊441021

出　　处：《临床急诊杂志》2005年第2期18-19,共2页Journal of Clinical Emergency

摘　　要：目的探讨白细胞介素-8(IL-8),白细胞介素-17(IL-17)在慢性阻塞性肺疾病(COPD)发生机制中的作用。方法采用酶联免疫吸附法(ELISA)对 COPD 急性发作期患者(23例)及正常对照组(21例)痰 IL-8、IL-17水平进行检测。结果 COPD患者急性发作期痰 IL-8、IL-17水平明显高于正常对照组(P<0.01)。COPD 患者痰中 IL-8与1秒率(FEV_1)呈显著负相关(r=-0.746,P<0.01)。COPD 患者及正常对照组痰中 IL-8与 IL-17均呈显著正相关(r=0.727,P<0.01;r=0.774,P<0.01)。结论 IL-8及 IL-17均参与了 COPD 的发病过程,且 IL-17与 IL-8在 COPD 发病过程中关系密切。IL-17可能多经由 IL-8发挥作用。Objective To explore the role of interleukin-8(IL-8),interleukin-17(IL-17)in pathogenesis of chronic obstructive pul- anonary disease(COPD).Methods IL-8 and IL-17 of sputum in 23 patients with acute exacerbation of COPD and in 21 normal subjects were detectad by ELISA method.Results IL-8 and IL-17 of spatum in 23 patients with acute COPD was much higher than that of sputum in normal subjects(P<0.01).And there was highly negative correlation between IL-17 of sputum and FEV_1 in patients with acute COPD(r =0.746,P<0.01).In addition,there was highly positive correlation between IL-8 and IL-17 of sputum in patients with COPD and in nor- mal subjects(r=0.727,P<0.01;r=0.774,P<0.01).Conclusion:IL-8 and IL-17 played an important role in the pathogenesis of COPD.Relationship of IL-8 and IL-17 was near.IL-17 possibly played a role in COPD by IL-8 modulating.

关 键 词：慢性阻塞性肺病 白细胞介素-8 白细胞介素-17 气道炎症 

分 类 号：R563[医药卫生—呼吸系统]