电离辐射对不同肿瘤细胞细胞周期进程的影响  

Changes of cell cycle progression of tumor cells irradiated by ^(60)Co γ-rays

作　　者：夏景光[1] 李文建[1] 魏巍[1] 赵靖[1] 金晓东[1] 

机构地区：[1]中国科学院近代物理研究所

出　　处：《辐射研究与辐射工艺学报》2005年第2期91-91,共1页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金重点资助(10335050)资助

摘　　要：Human tumor cell lines of SMMC-7721 (liver cancer), hepG2 (liver cancer), HO-8910 (ovary cancer), and Hela (cervix cancer) were irradiated to 3Gy by Co γ rays and different cell cycle responses were found. The re- 60 sults showed that the SMMC-7721, hepG2 and HO-8910 cells displayed G2 / M phase arrest and S phase tempo- rally delayed after the irradiation. The Hela cells had an increased number of cells in both G2 / M and S phase, which indicated that the G2 / M and S checkpoints were both activated.Human tumor cell lines of SMMC-7721 (liver cancer), hepG2 (liver cancer), HO-8910 (ovary cancer), and Hela (cervix cancer) were irradiated to 3Gy by Co γ rays and different cell cycle responses were found. The re- 60 sults showed that the SMMC-7721, hepG2 and HO-8910 cells displayed G2 / M phase arrest and S phase tempo- rally delayed after the irradiation. The Hela cells had an increased number of cells in both G2 / M and S phase, which indicated that the G2 / M and S checkpoints were both activated.

关 键 词：肿瘤细胞 细胞周期阻滞 ^60Cγ射线照射 

分 类 号：Q691[生物学—生物物理学]