N-芳基(烷基)-N′-芳基(烷基)-N″-(葡萄糖基硫代亚脲基)膦酰三胺的合成  

Synthesis of N-aryl(alkyl)-N′-aryl(alkyl)-N″-(glucosyl thiouseyiene) phosphoric triamides

作　　者：解正峰[1] 曹玲华[1] 

机构地区：[1]新疆大学化学化工学院化学系

出　　处：《化学研究与应用》2005年第2期245-248,共4页Chemical Research and Application

基　　金：国家自然科学基金资助项目 (2 9962 0 0 2 );南开大学元素有机化学国家重点实验室开放基金资助项目

摘　　要：N-substituted phosphoramidic chloride was obtained from the reaction of amines with POCl3,then hydrazinolyzation gave N-substituted phosphoramidohydrazide（2a-2g）.Refluxing of 2 with glucosyl isothiocyanate（1）in CHCl3 gave corresponding N,N′-substituted-N″-（2,3,4,6-tetra-O-acetylglucosylthioureylene）phosphoric triamides（3a-3g）,and deacetylation in MeOH/NaOMe gave N,N’-substituted-N″-glucosy1 thioureylene phosphoric triamides（4a-4g）.Their structures were confirmed by IR,1H NNR,31P NMR,MS and elemental analysis.N-substituted phosphoramidic chloride was obtained from the reaction of amines with POCl_3,then hydrazinolyzation gave N-substituted phosphoramidohydrazide(2a-2g).Refluxing of 2 with glucosyl isothiocyanate(1)in CHCl_3 gave corresponding N,N′-substituted-N″-(2,3,4,6-tetra-O-acetylglucosylthioureylene)phosphoric triamides(3a-3g),and deacetylation in MeOH/NaOMe gave N,N'-substituted-N″-glucosy1 thioureylene phosphoric triamides(4a-4g).Their structures were confirmed by IR,~1H NNR,^(31)P NMR,MS and elemental analysis.

关 键 词：葡萄糖基异硫氰酸酯 膦酰二氨基肼 膦酰三胺 合成 

分 类 号：O629.9[理学—有机化学]