阴道镜拟诊外阴HPV亚临床感染105例临床分析  

Colposcopy Diagnosed Subclinical Vulvae HPV Infection:a Clinical Analysis of 105 Cases

作　　者：邓新粮[1] 武继承[1] 肖松舒[1] 

机构地区：[1]中南大学湘雅三医院,湖南长沙410013

出　　处：《实用预防医学》2005年第2期322-323,共2页Practical Preventive Medicine

摘　　要：目的　探讨外阴人乳头瘤病毒亚临床感染(SPI)的诊断及治疗。　方法　观察分析10 5例阴道镜拟诊外阴SPI的镜下特点、病理诊断,免疫组化检测HPV6、11、16、18型以及外阴SPI的治疗。　结果　10 5例拟诊外阴SPI的阴道镜特点均为病变区涂醋酸后变白。10 5例病检结果为:95例报告为外阴慢性增殖性炎症,7例报告为尖锐湿疣(CA) ,3例为外阴轻度不典型增生(VINⅠ)。HPV 6、11、16、18型免疫组化检测阳性66例,阴性3 9例。外阴SPI的治疗采取药物治疗或药物与物理治疗相结合,3个月治愈率73 .3 3 % ,6个月治愈率87.62 % ,9个月治愈率97.14 %。　结论　HPV感染早期可能没有典型的挖空细胞,而仅表现为慢性增殖性炎症,阴道镜及醋酸白试验可用于外阴SPI的初步诊断。Objective The diagnosis and treatment of subclinical vulvae human papilloma virus infection (SPI) were studied. Methods Colposcopic, histopathological and immunohistochemical characteristics of 105 cases of vulvae SPI with HPV 6,11,16,18 infections, and the treatment of vulvae SPI were reviewed. Results The lesions of all the 105 cases vulvae SPI were become white after painted with acetic acid under colposcopic inspection. Of the 105 cases pathological reports, 95 were reported chronic proliferating inflammation, 7 condyloma acuminate(CA),and 3 mild vulvae intraepithelial atypical hyperplasia I(VIN I). Further immunohistochemical examination of HPV 6,11,16,18, 66 cases showed positive and 39 negative. The treatment of valvae SPI was drug therapy or drug combined physical therapy. The 3-month cure rate was 73.33%, 6-month 87.62%, and 9-month 97.13%. Conclusions The early stage of HPV infection may present only chronic proliferating inflammation in absence of koilocytes. Colposcopy and acetic acid white test provides preliminary diagnosis for vulvae SPI. The optimal treatment is drug combined physical therapy.

关 键 词：外阴SPI HPV 阴道镜 醋酸白试验 

分 类 号：R711.7[医药卫生—妇产科学]