过敏性紫癜患儿血清IL-8和IL-12的水平及其意义  

Clinical Significance of the Changes of Serum IL-8 and IL-12 Levels in Pediatric Patients with Anaphylactoid Purpura (AP)

作　　者：梁振明[1] 刘霞[1] 

机构地区：[1]杭州市第二人民医院,310000

出　　处：《放射免疫学杂志》2005年第2期139-140,共2页Journal of Radioimmanology

摘　　要：目的:旨在探讨IL-8和IL-12在AP和在APN发病机制中的作用及其相互关系,期望在AP的治疗方面提供一些新的理论依据。方法:检测32例AP、11例APN和15例正常儿童血清中IL-8、IL-12的变化,并分析它们之间的相关性意义。结果:过敏性紫癜患儿急性期血清中IL-8、IL-12的含量无论普通组还是肾损害组均显著高于对照组,恢复期IL-8和IL-12仍高于正常对照组。急性期IL-8和IL-12呈正相关性。说明二者共同参与了过敏性紫癜的发病过程。结论:本实验说明了IL-8和IL-12共同参与了过敏性紫癜的发病过程,尤其在紫癜性肾炎中,为IL-8、IL-12拮抗剂在过敏性紫癜治疗中的应用提供了客观依据。Objective To explore the role of IL-8 and IL-12 in the pathogenesis of anaphylactoid purpura (AP) and anaphylactoid purpura nephritis (APN). Methods Serum IL-8 (with RIA) and IL-12 (with ELISA) levels were measured in 32 pediatric patients with anaphylactoid purpura (AP),11 pediatric patients with anaphylactoid purpura nephritis (APN) and 15 controls. Results During acute stage, serum IL-8 and IL-12 levels in both the AP and APN patients were significantly higher than those in controls and remained higher during convalescence. IL-8 and IL-12 levels were mutually positively correlated in acute stage. Conclusion IL-8 and IL-12 participated in the pathogenesis of AP and APN. Theoretically, antagonist to those cytokines might be of clinical benefits.

关 键 词：过敏性紫癜 患儿 血清 IL-8 IL-12 

分 类 号：R725.546[医药卫生—儿科]