高分子负载的羟基脯氨酸催化丙酮与邻-和对-硝基苯甲醛的不对称直接Aldol加成反应(英文)  

Polymer-Supported Hydroxyproline as a Catalyst for Direct Asymmetric Aldol Addition of Acetone to o-And p-Nitrobenzaldehyde

作　　者：马济美[1] 张雅文[1] 罗晓清[2] 汪杨[1] 刘艳华[1] 沈宗旋[1] 

机构地区：[1]江苏省有机合成重点实验室苏州大学化学化工学院,苏州215006 [2]苏州卫生学校,苏州215007

出　　处：《分子催化》2005年第2期126-130,共5页Journal of Molecular Catalysis(China)

基　　金：TheprojectwassupportedbytheKeyLaboratoryofOrganicSynthesisofJiangsuProvince(JSK015).

摘　　要：以4(R)-羟基脯氨酸为原料,合成了高分子负载的脯氨酸衍生物,并用来催化丙酮对邻-和对-硝基苯甲醛的直接不对称Aldol加成反应,ee值最高可达80%,催化剂至少可以重复利用三次.Starting from (4R)-hydroxy-L-proline, a polymer-supported proline derivative has been prepared and conducted as a catalyst in the direct asymmetric aldol addition of acetone to o- and p- nitrobenzaldehyde. The desired aldol adducts were obtained in good yields with ee's up to 80%, and the catalyst can be reused for at least three times.

关 键 词：PMBHA树脂 手性催化剂 羟醛缩合反应 羟基脯氨酸 回收 

分 类 号：O643.32[理学—物理化学]